Current Clinical Recommendations for Use of Platelet-Rich Plasma.
TLDR
Evidence of its efficacy has been highly variable depending on the specific indication, and additional high-quality clinical trials with longer follow-up will be critical in shaping the perspective of this treatment option.Abstract:
This review evaluates current clinical literature on the use of platelet-rich plasma (PRP), including leukocyte-rich PRP (LR-PRP) and leukocyte-poor PRP (LP-PRP), in order to develop evidence-based recommendations for various musculoskeletal indications. Abundant high-quality evidence supports the use of LR-PRP injection for lateral epicondylitis and LP-PRP for osteoarthritis of the knee. Moderate high-quality evidence supports the use of LR-PRP injection for patellar tendinopathy and of PRP injection for plantar fasciitis and donor site pain in patellar tendon graft BTB ACL reconstruction. There is insufficient evidence to routinely recommend PRP for rotator cuff tendinopathy, osteoarthritis of the hip, or high ankle sprains. Current evidence demonstrates a lack of efficacy of PRP for Achilles tendinopathy, muscle injuries, acute fracture or nonunion, surgical augmentation in rotator cuff repair, Achilles tendon repair, and ACL reconstruction. PRP is a promising treatment for some musculoskeletal diseases; however, evidence of its efficacy has been highly variable depending on the specific indication. Additional high-quality clinical trials with longer follow-up will be critical in shaping our perspective of this treatment option.read more
Citations
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Platelet Concentrates in Musculoskeletal Medicine
Erminia Mariani,Lia Pulsatelli +1 more
TL;DR: This narrative review focuses on three main topics concerning the use of platelet concentrate for treating musculoskeletal conditions: (a) the different procedures to prepare PCs, (b) the composition of PCs that is related to the type of methodological procedure adopted and (c) the clinical application in musculOSkeletal medicine, efficacy and main limits of the different studies.
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Classification systems for platelet-rich plasma
Luciano A. Rossi,Iain R. Murray,Constance R. Chu,George F. Muschler,Scott A. Rodeo,Nicolas S. Piuzzi +5 more
TL;DR: There remains a need for standardized universal nomenclature to describe biological therapies, as well as a comprehensive and reproducible classification system for autologous blood-derived products.
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Improved outcomes after mesenchymal stem cells injections for knee osteoarthritis: results at 12-months follow-up: a systematic review of the literature.
Filippo Migliorini,Björn Rath,Giorgia Colarossi,Arne Driessen,Markus Tingart,Marc Niewiera,Jörg Eschweiler +6 more
TL;DR: It is reported that MSC infiltrations for knee OA can represent a feasible option, leading to an overall remarkable improvement of all clinical and functional considered outcomes, regardless of the cell source.
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Platelet-Rich Plasma in Patients With Partial-Thickness Rotator Cuff Tears or Tendinopathy Leads to Significantly Improved Short-Term Pain Relief and Function Compared With Corticosteroid Injection: A Double-Blind Randomized Controlled Trial
Cory A. Kwong,Jarret M. Woodmass,Eva M. Gusnowski,Aaron J. Bois,Justin LeBlanc,Kristie D More,Ian K.Y. Lo +6 more
TL;DR: There was no sustained benefit of PRP over CS at longer-term follow-up (12 months), and patients with PTRCTs or tendinopathy experienced clinical improvement in pain and patient-reported outcome scores after both ultrasound-guided CS and PRP injections.
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Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses.
TL;DR: For short-term follow-up, intra-articular PRP injection is more effective in terms of pain relief and function improvement in the treatment of KOA patients than HA and placebo, and there is no difference in the risk of an adverse event between PRP and HA or placebo.
References
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Journal ArticleDOI
Use of NeuroEyeCoach™ to Improve Eye Movement Efficacy in Patients with Homonymous Visual Field Loss.
TL;DR: NEC can be used as an effective rehabilitation tool to develop compensatory strategies in patients with visual field deficits after brain injury and improvements in patients were significantly greater than those in a group of healthy adults.
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Platelet-rich plasma (PRP): what is PRP and what is not PRP?
TL;DR: The definition of PRP, its safety, its proper development, and its most efficacious means of application are discussed.
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Platelet-Rich Plasma From Basic Science to Clinical Applications
TL;DR: This study reviews and evaluates the human studies that have been published in the orthopaedic surgery and sports medicine literature and the regulation of PRP by antidoping agencies is discussed.
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Large Artery Remodeling and Dynamics following Simulated Microgravity by Prolonged Head-Down Tilt Bed Rest in Humans
Carlo Palombo,Carmela Morizzo,Martino Baluci,Daniela Lucini,Stefano Ricci,Gianni Biolo,Piero Tortoli,Michaela Kozakova +7 more
TL;DR: Extended HDTBR has a different impact on CCA and CFA structure and flow, probably depending on the characteristics of the vascular bed perfused.
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Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial Platelet-Rich Plasma Versus Corticosteroid Injection With a 1-Year Follow-up
TL;DR: Treatment of patients with chronic lateral epicondylitis with PRP reduces pain and significantly increases function, exceeding the effect of corticosteroid injection.