M
Marc D. Breton
Researcher at University of Virginia
Publications - 206
Citations - 7723
Marc D. Breton is an academic researcher from University of Virginia. The author has contributed to research in topics: Insulin & Type 1 diabetes. The author has an hindex of 40, co-authored 181 publications receiving 6392 citations. Previous affiliations of Marc D. Breton include Virginia Commonwealth University & University of Virginia Health System.
Papers
More filters
Journal ArticleDOI
In Silico Preclinical Trials: A Proof of Concept in Closed-Loop Control of Type 1 Diabetes
TL;DR: A system for in silico testing of control algorithms that has been shown to represent adequate glucose fluctuations in T1DM observed during meal challenges, and has been accepted by the Food and Drug Administration as a substitute to animal trials in the preclinical testing of closed-loop control strategies.
Journal ArticleDOI
The UVA/PADOVA Type 1 Diabetes Simulator New Features
Chiara Dalla Man,Francesco Micheletto,Dayu Lv,Marc D. Breton,Boris Kovatchev,Claudio Cobelli +5 more
TL;DR: A new version of the UVA/PADOVA Type 1 Diabetes Simulator, which was submitted to FDA in 2013, provides a more reliable framework for in silico trials, for testing glucose sensors and insulin augmented pump prediction methods, and for closed-loop single/dual hormone controller design, testing, and validation.
Journal ArticleDOI
Fully Integrated Artificial Pancreas in Type 1 Diabetes: Modular Closed-Loop Glucose Control Maintains Near Normoglycemia
Marc D. Breton,Anne Farret,Daniela Bruttomesso,Stacey M. Anderson,Lalo Magni,Stephen D. Patek,Chiara Dalla Man,Jerome Place,Susan Demartini,Simone Del Favero,Chiara Toffanin,Colleen Hughes-Karvetski,Eyal Dassau,Howard Zisser,Francis J. Doyle,Giuseppe De Nicolao,Angelo Avogaro,Claudio Cobelli,Eric Renard,Boris Kovatchev +19 more
TL;DR: In this article, the authors presented a modular concept for integrated closed-loop control (CLC) design, illustrated by clinical studies involving 11 adolescents and 27 adults at the Universities of Virginia, Padova, and Montpellier.
Journal ArticleDOI
A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes
Marc D. Breton,Lauren Kanapka,Roy W. Beck,Laya Ekhlaspour,Gregory P. Forlenza,Eda Cengiz,Melissa J Schoelwer,Katrina J. Ruedy,Emily Jost,Lori Carria,Emma Emory,Liana J Hsu,Mary C. Oliveri,Kollman C,Betsy B Dokken,Stuart A. Weinzimer,Mark D. DeBoer,Bruce A. Buckingham,Daniel R. Cherñavvsky,R. Paul Wadwa +19 more
TL;DR: In this 16-week trial involving children with type 1 diabetes, the glucose level was in the target range for a greater percentage of time with the use of a closed-loop system than with theUse of a sensor-augmented insulin pump.
Journal ArticleDOI
Multinational study of subcutaneous model-predictive closed-loop control in type 1 diabetes mellitus: summary of the results.
Boris Kovatchev,Claudio Cobelli,Eric Renard,Stacey M. Anderson,Marc D. Breton,Stephen D. Patek,William L. Clarke,Daniela Bruttomesso,Alberto Maran,S. Costa,Angelo Avogaro,Chiara Dalla Man,Andrea Facchinetti,Lalo Magni,Giuseppe De Nicolao,Jerome Place,Anne Farret +16 more
TL;DR: Close-loop control improves the overnight regulation of diabetes and can be used as viable alternatives to animal trials for the preclinical testing of insulin treatment strategies.