M
Matthew L. Goodwin
Researcher at Johns Hopkins University School of Medicine
Publications - 64
Citations - 1670
Matthew L. Goodwin is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Medicine & Skeletal muscle. The author has an hindex of 15, co-authored 56 publications receiving 1175 citations. Previous affiliations of Matthew L. Goodwin include Washington University in St. Louis & Barnes-Jewish Hospital.
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Journal ArticleDOI
Blood Lactate Measurements and Analysis during Exercise: A Guide for Clinicians
TL;DR: Blood lactate concentration ([La−]b) is one of the most often measured parameters during clinical exercise testing as well as during performance testing of athletes and is useful in prescribing exercise intensities for most diseased and nondiseased patients alike.
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Lactate is always the end product of glycolysis
TL;DR: The proposition, analogous to the phosphocreatine shuttle, purports that pyruvate, NAD+, NADH, and La− are held uniformly near equilibrium throughout the cell cytosol due to the high activity of LDH.
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Lactate Metabolism: Historical Context, Prior Misinterpretations, And Current Understanding
Brian S. Ferguson,Matthew J. Rogatzki,Matthew L. Goodwin,Matthew L. Goodwin,Daniel A. Kane,Zachary B Rightmire,L. Bruce Gladden +6 more
TL;DR: Current understanding of La− metabolism is synthesized via an appraisal of its robust experimental history, particularly in exercise physiology, to highlight La−’s central role in metabolism and amplifies the understanding of past research.
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Lactate and Cancer: Revisiting the Warburg Effect in an Era of Lactate Shuttling
Matthew L. Goodwin,Matthew L. Goodwin,L. Bruce Gladden,Maarten W. N. Nijsten,Kevin B. Jones,Kevin B. Jones +5 more
TL;DR: A brief overview of some of the recent developments in the ever expanding literature on lactate metabolism and cancer is presented.
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Mitochondrial lactate metabolism: history and implications for exercise and disease
Brian Glancy,Daniel A. Kane,Andreas N. Kavazis,Matthew L. Goodwin,Wayne T. Willis,L. Bruce Gladden +5 more
TL;DR: It is argued that lactate is not directly oxidized in the mitochondrial matrix, and the interim glycolytic products (pyruvate and NADH) are held in cytosolic equilibrium with the products of the lactate dehydrogenase (LDH) reaction and the intermediates of the malate‐aspartate and glycerol 3‐phosphate shuttles.