Michael D. Buschmann

TL;DR: This study reports for the first time the use of polymer/polyol salt aqueous solutions as gelling systems, suggesting the discovery of a prototype for a new family of thermosetting gels highly compatible with biological compounds.

TL;DR: In this article, the effect of static and dynamic mechanical compression on the biosynthetic activity of chondrocytes cultured within agarose gel was studied, and it was shown that the presence or absence of matrix, as well as the physical properties of the disks, suggested that cell-matrix interactions (e.g. mechanical and/or receptor mediated) and extracellular physicochemical effects (increased [Na+], reduced pH) may be more important than matrix-independent cell deformation and transport limitations in determining the response to static compression.

TL;DR: A method for the determination of the degree of deacetylation of chitosan by 1H NMR spectroscopy has been formally validated and is found to be simple, rapid and more precise than other known techniques like IR or titration for %DDA measurements.

TL;DR: Results suggested the formation of mechanically functional matrix in calf articular cartilage‐like extracellular matrix quantified in high cell density agarose gel culture.

TL;DR: It is demonstrated that chitosan solutions can be neutralised up to physiological pH (∼7.2) using β-glycerol phosphate without creating immediate gel-like precipitation and furthermore that subsequent heating of these solutions induces hydrogel formation.