C
Caroline D. Hoemann
Researcher at École Polytechnique de Montréal
Publications - 110
Citations - 7179
Caroline D. Hoemann is an academic researcher from École Polytechnique de Montréal. The author has contributed to research in topics: Cartilage & Chondrocyte. The author has an hindex of 39, co-authored 109 publications receiving 6647 citations. Previous affiliations of Caroline D. Hoemann include Laboratory of Molecular Biology & École Polytechnique.
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Journal ArticleDOI
Novel injectable neutral solutions of chitosan form biodegradable gels in situ
Abdellatif Chenite,C Chaput,Dadong Wang,C Combes,Michael D. Buschmann,Caroline D. Hoemann,Jean-Christophe Leroux,B.L Atkinson,F Binette,A Selmani +9 more
TL;DR: This study reports for the first time the use of polymer/polyol salt aqueous solutions as gelling systems, suggesting the discovery of a prototype for a new family of thermosetting gels highly compatible with biological compounds.
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Tissue engineering of cartilage using an injectable and adhesive chitosan-based cell-delivery vehicle.
TL;DR: The in situ-gelling chitosan solution described here can support in vitro and in vivo accumulation of cartilage matrix by primary chondrocytes, while persisting in osteochondral defects at least 1 week in vivo.
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Chitosan-glycerol phosphate/blood implants improve hyaline cartilage repair in ovine microfracture defects.
Caroline D. Hoemann,Mark Hurtig,Evgeny Rossomacha,Jun Sun,Anik Chevrier,Matthew S. Shive,Michael D. Buschmann +6 more
TL;DR: Solidification of a chitosan-glycerol phosphate/blood implant in microfracture defects improved cartilage repair compared with microfractionure alone by increasing the amount of tissue and improving its biochemical composition and cellular organization.
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In vitro osteogenesis assays: influence of the primary cell source on alkaline phosphatase activity and mineralization.
TL;DR: A comparative analysis of published osteogenic assays using calvarial cells, calvaria-derived cell lines, and bone marrow stromal cells shows similar progression over time using a variety of osteogenic and mineralizing media conditions; however, levels of alkaline phosphatase activity are not proportional to observed mineralization levels.
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The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementation.
Peter J. Roughley,Caroline D. Hoemann,Eric DesRosiers,Fackson Mwale,John Antoniou,Mauro Alini +5 more
TL;DR: The results support the concept that chitosan may be a suitable scaffold for cell-based supplementation to help restore the function of the NP during the early stages of IVD degeneration.