Michiel van der Vaart

TL;DR: The pattern recognition receptors that identify invading microbes, as well as the innate immune effector mechanisms that they activate in zebrafish embryos are reviewed and compared to the current knowledge about these processes in mammalian models and zebra fish.

TL;DR: Analysis in zebrafish and human macrophage models of mycobacterial infection reveals that the DNA damage-regulated autophagy modulator DRAM1 functions downstream of pathogen recognition by the Toll-like receptor (TLR)/interleukin-1 receptor (IL1R)-MYD88-NF-κB innate immune sensing pathway to activate selective Autophagy.

TL;DR: It is shown that this immune-compromised zebrafish mutant has a lower survival rate under standard rearing conditions and is more susceptible to challenge with the acute bacterial pathogens Edwardsiella tarda and Salmonella typhimurium.

TL;DR: Results indicate that induction of leukocyte iNOS by stabilizing Hif-1α, or reducing H if-2α, aids the host during early stages of Mm infection, and represents a potential target for therapeutic intervention against tuberculosis.

TL;DR: The results argue that zebrafish embryos offer a powerful system for monitoring NPs in vivo and rationalize why NP therapy was so effective against Mtb in earlier studies; bacteria and NPs share the same cellular niche.