Mohan Srinivasan

TL;DR: In this paper, isolated monoclonal antibodies particularly human antibody that specifically bind to PD-L1 with high affinity are provided. And methods for detecting PDL1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PDL1 antibodies.

TL;DR: Data suggest that anti-CTLA-4 promotes antitumor activity by a selective reduction of intratumoral Tregs along with concomitant activation of Teffs.

TL;DR: In vitro assays demonstrated the ability of nivolumab to potently enhance T-cell responses and cytokine production in the mixed lymphocyte reaction and superantigen or cytomegalovirus stimulation assays, and no in vitro antibody-dependent cell-mediated or complement-dependent cytotoxicity was observed with the use of n ivolumAB and activated T cells as targets.

TL;DR: The expression of human mAbs in the small aquatic plant Lemna minor offers several advantages for manufacturing therapeutic proteins free of zoonotic pathogens and had better antibody-dependent cell-mediated cytotoxicity and effector cell receptor binding activities than mAbs expressed in cultured Chinese hamster ovary (CHO) cells.

TL;DR: The ability of upstream and downstream DNA sequences of ovalbumin, a protein produced exclusively in very high quantities in chicken egg white, to drive tissue-specific expression of human mAb in chicken eggs is examined.