T
Timothy Chen
Researcher at Bristol-Myers Squibb
Publications - 2
Citations - 736
Timothy Chen is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Antibody & CD8. The author has an hindex of 2, co-authored 2 publications receiving 623 citations.
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Journal ArticleDOI
Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells.
Mark J. Selby,John J. Engelhardt,Michael Quigley,Karla A. Henning,Timothy Chen,Mohan Srinivasan,Alan J. Korman +6 more
TL;DR: Data suggest that anti-CTLA-4 promotes antitumor activity by a selective reduction of intratumoral Tregs along with concomitant activation of Teffs.
Journal ArticleDOI
Role of the immunoglobulin constant region in the antitumor activity of antibodies to cytotoxic T-lymphocyte antigen-4 (CTLA-4).
Alan J. Korman,John J. Engelhardt,Vafa Shahabi,Roumyana Yordanova,Karla A. Henning,Timothy Chen,Mark J. Selby +6 more
TL;DR: This work examined the role of the immunoglobulin constant region in the antitumor activity of anti-CTLA-4 Abs in mouse tumor models and identified polymorphisms in the IgG fragment c receptor (FcR) at FCGR3A (V158F) and FCGR2A (H131R) loci.