M
Monica R. Maiello
Researcher at Yahoo!
Publications - 42
Citations - 4964
Monica R. Maiello is an academic researcher from Yahoo!. The author has contributed to research in topics: Epidermal growth factor receptor & Cancer. The author has an hindex of 21, co-authored 39 publications receiving 4424 citations.
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Journal ArticleDOI
Epidermal growth factor receptor (EGFR) signaling in cancer
Nicola Normanno,Antonella De Luca,Caterina Bianco,Luigi Strizzi,Mario Mancino,Monica R. Maiello,Adele Carotenuto,Gianfranco De Feo,Francesco Caponigro,David S. Salomon +9 more
TL;DR: The growth and the survival of carcinoma cells appear to be sustained by a network of receptors/ligands of the ErbB family, which is important for therapeutic approaches, since the response to anti-EGFR agents might depend on the total level of expression ofErbB receptors and ligands in tumor cells.
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The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches.
TL;DR: A large-scale characterization of the cancer genome might offer personalized cancer genomic information, which may improve the anti-tumor efficacy of signalling inhibitors.
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Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment.
TL;DR: The mechanisms of action of these compounds, as well as the potential therapeutic strategies to improve their efficacy are discussed in this review with particular regard to the combinations of anti-ErbB agents with cytotoxic drugs, or combinations of different ErbB-targeting agents.
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The role of the EGFR signaling in tumor microenvironment
Antonella De Luca,Adele Carotenuto,Annamaria Rachiglio,Marianna Gallo,Monica R. Maiello,Donatella Aldinucci,Antonio Pinto,Nicola Normanno +7 more
TL;DR: Findings suggest that the EGFR system is an important mediator, within the tumor microenvironment, of autocrine and paracrine circuits that result in enhanced tumor growth.
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Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth
Nicola Normanno,Manuela Campiglio,A. De Luca,Giulia Somenzi,Monica R. Maiello,Fortunato Ciardiello,Luca Gianni,David S. Salomon,Sylvie Ménard +8 more
TL;DR: Combined treatment with drugs that target EGFR and ErbB-2 might result in an efficient inhibition of tumor growth in those breast carcinoma patients whose tumors co-express both receptors.