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Nicola Normanno
Researcher at Yahoo!
Publications - 392
Citations - 23452
Nicola Normanno is an academic researcher from Yahoo!. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 66, co-authored 337 publications receiving 19605 citations. Previous affiliations of Nicola Normanno include National Institutes of Health & University of Washington.
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Journal ArticleDOI
Epidermal growth factor-related peptides and their receptors in human malignancies
Journal ArticleDOI
ESMO consensus guidelines for the management of patients with metastatic colorectal cancer
E. Van Cutsem,Andrés Cervantes,René Adam,Alberto Sobrero,J.H.J.M. van Krieken,Dan Aderka,E. Aranda Aguilar,Alberto Bardelli,Al B. Benson,György Bodoky,Fortunato Ciardiello,André D'Hoore,Eduardo Díaz-Rubio,J.-Y. Douillard,Michel Ducreux,Alfredo Falcone,Axel Grothey,Thomas Gruenberger,Karin Haustermans,Volker Heinemann,Paulo M. Hoff,C.-H. Köhne,R. Labianca,Pierre Laurent-Puig,Brigette B.Y. Ma,Tim Maughan,Kei Muro,Nicola Normanno,Pia Österlund,Pia Österlund,Wim J.G. Oyen,Demetris Papamichael,George Pentheroudakis,Per Pfeiffer,Timothy J. Price,C.J.A. Punt,Jens Ricke,Arnaud Roth,R. Salazar,Werner Scheithauer,H.-J. Schmoll,Josep Tabernero,Julien Taieb,Sabine Tejpar,Harpreet Wasan,Takayuki Yoshino,Aziz Zaanan,Dirk Arnold +47 more
TL;DR: These ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.
Journal ArticleDOI
Epidermal growth factor receptor (EGFR) signaling in cancer
Nicola Normanno,Antonella De Luca,Caterina Bianco,Luigi Strizzi,Mario Mancino,Monica R. Maiello,Adele Carotenuto,Gianfranco De Feo,Francesco Caponigro,David S. Salomon +9 more
TL;DR: The growth and the survival of carcinoma cells appear to be sustained by a network of receptors/ligands of the ErbB family, which is important for therapeutic approaches, since the response to anti-EGFR agents might depend on the total level of expression ofErbB receptors and ligands in tumor cells.
Journal ArticleDOI
The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches.
TL;DR: A large-scale characterization of the cancer genome might offer personalized cancer genomic information, which may improve the anti-tumor efficacy of signalling inhibitors.
Journal ArticleDOI
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
F. Mosele,Jordi Remon,Joaquin Mateo,C. B. Westphalen,Fabrice Barlesi,Martijn P. Lolkema,Nicola Normanno,Aldo Scarpa,Mark E. Robson,Funda Meric-Bernstam,Nikhil Wagle,Albrecht Stenzinger,Julia Bonastre,A. Bayle,Stefan Michiels,Ivan Bièche,Etienne Rouleau,S. Jezdic,J.-Y. Douillard,Jorge S. Reis-Filho,R. Dienstmann,Fabrice Andre +21 more
TL;DR: ESMO recommends routine use of NGS on tumour samples in advanced non-squamous NSCLC, prostate cancers, ovarian cancers and cholangiocarcinoma, and develops multigene sequencing as a tool to screen patients eligible for clinical trials and to accelerate drug development.