M
Munehiro Kitada
Researcher at Kanazawa Medical University
Publications - 98
Citations - 5451
Munehiro Kitada is an academic researcher from Kanazawa Medical University. The author has contributed to research in topics: Diabetes mellitus & Diabetic nephropathy. The author has an hindex of 34, co-authored 94 publications receiving 4032 citations. Previous affiliations of Munehiro Kitada include Joslin Diabetes Center & Harvard University.
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Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway.
TL;DR: RSV significantly reduced UAE and attenuated renal pathological changes in db/db mice and has antioxidative activities via AMPK/SIRT1-independent pathway, through improvement of oxidative stress via normalization of Mn-SOD function and glucose-lipid metabolism.
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Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to-mesenchymal transition in a therapeutic regimen
Keizo Kanasaki,Sen Shi,Megumi Kanasaki,Jianhua He,Takako Nagai,Yuka Nakamura,Yasuhito Ishigaki,Munehiro Kitada,Swayam Prakash Srivastava,Daisuke Koya +9 more
TL;DR: It is found that the DPP-4 inhibitor linagliptin ameliorated kidney fibrosis in diabetic mice without altering the blood glucose levels associated with the inhibition of EndMT and the restoration of microRNA 29s.
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Effects of Antioxidants in Diabetes-Induced Oxidative Stress in the Glomeruli of Diabetic Rats
Daisuke Koya,Kazuyuki Hayashi,Munehiro Kitada,Atsunori Kashiwagi,Ryuichi Kikkawa,Masakazu Haneda +5 more
TL;DR: Glomerular ROS was imaged with the use of 2', 7'-dichlorofluorescein diacetate (DCFH-DA) and antioxidant treatment with either vitamin E or probucol almost completely normalized HO-1 overexpression in diabetic glomeruli, supporting the existence of oxidative stress in the glomersuli of early diabetes.
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Translocation of Glomerular p47phox and p67phox by Protein Kinase C-β Activation Is Required for Oxidative Stress in Diabetic Nephropathy
Munehiro Kitada,Daisuke Koya,Toshiro Sugimoto,Motohide Isono,Shin-ichi Araki,Atsunori Kashiwagi,Masakazu Haneda +6 more
TL;DR: It is demonstrated that oxidative stress is primarily enhanced in the diabetic glomeruli due to a PKC-beta-dependent activation of NADPH oxidase resulting in ROS generation.
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SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential
Munehiro Kitada,Daisuke Koya +1 more
TL;DR: Current understanding of the biological functions of SIRT1 is summarized and its potential as a promising therapeutic target for T2DM is discussed, implicating with CR.