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Daisuke Koya

Researcher at Kanazawa Medical University

Publications -  304
Citations -  22633

Daisuke Koya is an academic researcher from Kanazawa Medical University. The author has contributed to research in topics: Diabetes mellitus & Diabetic nephropathy. The author has an hindex of 67, co-authored 294 publications receiving 18746 citations. Previous affiliations of Daisuke Koya include Shiga University of Medical Science.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

TL;DR: The mechanisms underlying CR-mediated protection against hypoxia in aged kidney are investigated in mice, with a special focus on the role of the NAD-dependent deacetylase sirtuin 1 (Sirt1), which is linked to CR-related longevity in model organisms, on mitochondrial autophagy.
Journal ArticleDOI

SIRT1 and insulin resistance.

TL;DR: The findings suggest that SIRT1 might be a new therapeutic target for the prevention of disease related to insulin resistance, such as metabolic syndrome and diabetes mellitus, although direct evidence from clinical studies in humans is needed to prove this possibility.
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Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway.

TL;DR: RSV significantly reduced UAE and attenuated renal pathological changes in db/db mice and has antioxidative activities via AMPK/SIRT1-independent pathway, through improvement of oxidative stress via normalization of Mn-SOD function and glucose-lipid metabolism.