Nadja B. Cech

TL;DR: Fundamental studies of the ESI process are reviewed that are relevant to issues related to analyte chargeability and surface activity, and how accessible parameters such as nonpolar surface area and reversed phase HPLC retention time can be used to predict relative ESI response.

TL;DR: This report represents a critical review with commentary about the current state of the scientific literature as it relates to studying combination effects in natural product extracts, with particular emphasis on analytical and Big Data approaches for identifying synergistic or antagonistic combinations and elucidating the mechanisms that underlie their interactions.

TL;DR: This model suggests that because excess charge exists on ESI droplet surfaces, an analyte's relative affinity for the droplet surface determines its relative ESI response.

TL;DR: The effect of gas-phase proton transfer reactions on the mass spectral response of solvents and analytes with known gas- phase proton affinities was evaluated and the analyte response was suppressed or eliminated insolvents with gas- Phase Proton affinity higher than that of the analytes.

TL;DR: Findings show how members of the normal human skin microbiome can contribute to epithelial barrier homeostasis by using quorum sensing to inhibit S. aureus toxin production.