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Nan Jiang
Researcher at Hoffmann-La Roche
Publications - 1
Citations - 295
Nan Jiang is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Cell cycle checkpoint & Proteasome. The author has an hindex of 1, co-authored 1 publications receiving 231 citations.
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Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.
Binh Thanh Vu,Peter Michael Wovkulich,Giacomo Pizzolato,Allen John Lovey,Qingjie Ding,Nan Jiang,Jin-Jun Liu,Chunlin Zhao,Kelli Glenn,Yang Wen,Christian Tovar,Packman Kathryn E,Lyubomir T. Vassilev,Bradford Graves +13 more
TL;DR: RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket ofMDM2, which stabilizes p53 and activates the p 53 pathway, leading to cell cycle arrest, apoptosis, and inhibition or regression of human tumor xenografts.