P
Peter Michael Wovkulich
Researcher at Hoffmann-La Roche
Publications - 67
Citations - 1851
Peter Michael Wovkulich is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Ene reaction & Enantioselective synthesis. The author has an hindex of 18, co-authored 67 publications receiving 1714 citations. Previous affiliations of Peter Michael Wovkulich include Takeda Pharmaceutical Company & Wayne State University.
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Journal ArticleDOI
Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.
Binh Thanh Vu,Peter Michael Wovkulich,Giacomo Pizzolato,Allen John Lovey,Qingjie Ding,Nan Jiang,Jin-Jun Liu,Chunlin Zhao,Kelli Glenn,Yang Wen,Christian Tovar,Packman Kathryn E,Lyubomir T. Vassilev,Bradford Graves +13 more
TL;DR: RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket ofMDM2, which stabilizes p53 and activates the p 53 pathway, leading to cell cycle arrest, apoptosis, and inhibition or regression of human tumor xenografts.
Journal ArticleDOI
MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models
Christian Tovar,Bradford Graves,Packman Kathryn E,Zoran Filipovic,Brian Higgins,Mingxuan Xia,Christine Tardell,Rosario Garrido,Edmund Lee,Kenneth Kolinsky,Kwong-Him To,Michael Linn,Frank John Podlaski,Peter Michael Wovkulich,Binh Thanh Vu,Lyubomir T. Vassilev +15 more
TL;DR: These findings offer a preclinical proof-of-concept that RG7112 is effective in treatment of solid tumors expressing wild-type p53, and a potent and selective member of the nutlin family of MDM2 antagonists currently in phase I clinical studies.
Journal ArticleDOI
Total synthesis of 1233A
TL;DR: In this article, the total synthesis of the HMG-CoA synthase inhibitor 1233A (1) starting from either (R)-pulegone (6) or diketo ester 12, is described.
Journal ArticleDOI
Direct α-iodination of cycloalkenones
Carl R. Johnson,Joseph P. Adams,Matthew P. Braun,C. B. W. Senanayake,Peter Michael Wovkulich,Milan R. Uskokovic +5 more
TL;DR: In this article, the direct preparation of α-iodoenones by treatment of enones with I 2 /pyridine in CCl 4 was described, and the enones were then treated with enones in order to obtain α-idoenones.
Journal ArticleDOI
Total synthesis of acosamine and daunosamine utilizing a diastereoselective intramolecular [3+2] cycloaddition
TL;DR: In this article, a diastereoselective intramolecular nitrone-olefin cyclization was used to synthesize daunosamine and acosamine.