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Neena Philips
Researcher at Fairleigh Dickinson University
Publications - 40
Citations - 1214
Neena Philips is an academic researcher from Fairleigh Dickinson University. The author has contributed to research in topics: Extracellular matrix & Photoaging. The author has an hindex of 17, co-authored 39 publications receiving 998 citations. Previous affiliations of Neena Philips include Georgian Court University.
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Journal ArticleDOI
Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals
R. J. Bosch,Neena Philips,Jorge A Suárez-Pérez,Jorge A Suárez-Pérez,Angeles Juarranz,Avani Devmurari,Jovinna Chalensouk-Khaosaat,Salvador González +7 more
TL;DR: The photoprotective strategies to prevent/treat photoaging and photocarcinogenesis include oral or topical agents that act as sunscreens or counteract the effects of UV radiation on DNA, cellular antioxidant balance, signal transduction pathways, immunology and the ECM.
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Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in ultraviolet radiation exposed fibroblasts, and keratinocytes.
TL;DR: Lower concentration of P. leucotomos (lower than 0.1%), may be beneficial in preventing photoaging by improving membrane integrity and inhibiting MMP-1, without increasing elastin expression.
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Beneficial regulation of matrixmetalloproteinases and their inhibitors, fibrillar collagens and transforming growth factor-β by Polypodium leucotomos, directly or in dermal fibroblasts, ultraviolet radiated fibroblasts, and melanoma cells
Neena Philips,Neena Philips,Jennifer Conte,Yu-Jun Chen,Prashanti Natrajan,May Taw,Thomas Keller,Joshua Givant,Marvin Tuason,Luiji Dulaj,Donna Leonardi,Salvador González +11 more
TL;DR: P. leucotomos demonstrated dual protective effects on the ECM via its inhibition of theECM proteolytic enzymes and the stimulation of the structural ECM collagens, and had predominant stimulatory effects on TGF-β expression in non-irradiated or UV radiated fibroblasts, and inhibited T GF- β expression in melanoma cells.
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Beneficial regulation of matrix metalloproteinases for skin health.
TL;DR: Matrix metalloproteinases are essential to the remodeling of the extracellular matrix and upregulation facilitates aging and cancer, and they areessential to epidermal differentiation and the prevention of wound scars.
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Stimulation of Cell Proliferation and Expression of Matrixmetalloproteinase-1 and Interluekin-8 Genes in Dermal Fibroblasts by Copper
TL;DR: The research suggests that copper facilitates wound healing as well as skin aging via the induction of MMP-1 expression, with limiting MMP effect at the higher concentrations through enhanced IL-8 expression, which favors extracellular matrix deposition.