Nicole A. Aqui

TL;DR: Combination immunotherapy consisting of a single early post-transplant infusion of in vivo vaccine-primed and ex vivo costimulated autologous T cells followed by post-Transplant booster immunizations improved the severe immunodeficiency associated with high-dose chemotherapy and led to the induction of clinically relevant immunity in adults within a month after transplantation.

TL;DR: It is concluded that CD25 blockade depletes and selectively reprograms Tregs in concert with active immune therapy in cancer patients, suggesting a mechanism to target cancer-associated T Regs while avoiding autoimmunity.

TL;DR: The use of a combinatorial lentiviral gene transfer approach is reported to achieve long-term stable expression of at least seven genes in the K562 parental cell line, which has therapeutic potential for adoptive immunotherapies and vaccinations.

TL;DR: PTLD patients requiring therapy beyond RI should be considered for rituximab, especially with EBV‐positive disease, and Chemotherapy should be reserved for patients who fail ritudine, haveEBV‐negative tumors or need a rapid response.