N
Niels Høiby
Researcher at University of Copenhagen
Publications - 604
Citations - 47805
Niels Høiby is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Pseudomonas aeruginosa & Cystic fibrosis. The author has an hindex of 105, co-authored 587 publications receiving 42859 citations. Previous affiliations of Niels Høiby include Florida International University & Massachusetts Institute of Technology.
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Antibiotic resistance of bacterial biofilms
TL;DR: Biofilms can be prevented by early aggressive antibiotic prophylaxis or therapy and they can be treated by chronic suppressive therapy and a promising strategy may be the use of enzymes that can dissolve the biofilm matrix as well as quorum-sensing inhibitors that increase biofilm susceptibility to antibiotics.
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Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors
Morten Hentzer,Hong Wu,Jens Bo Andersen,Kathrin Riedel,Thomas Bovbjerg Rasmussen,Niels Bagge,Naresh Kumar,Mark A. Schembri,Zhijun Song,Peter Kristoffersen,Mike Manefield,J. W. Costerton,Søren Molin,Leo Eberl,Peter D. Steinberg,Staffan Kjelleberg,Niels Høiby,Michael Givskov +17 more
TL;DR: A synthetic derivate of natural furanone compounds can act as a potent antagonist of bacterial quorum sensing and inhibited virulence factor expression in a mouse pulmonary infection model.
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Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound.
Morten Hentzer,Kathrin Riedel,Thomas Bovbjerg Rasmussen,Arne Heydorn,Jens Bo Andersen,Matthew R. Parsek,Scott A. Rice,Leo Eberl,Søren Molin,Niels Høiby,Staffan Kjelleberg,Michael Givskov +11 more
TL;DR: It is demonstrated that the furanone compound specifically represses expression of a PlasB-gfp reporter fusion without affecting growth or protein synthesis, indicating a general effect on target genes of the las quorum sensing circuit.
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Why chronic wounds will not heal: a novel hypothesis.
Thomas Bjarnsholt,Klaus Kirketerp-Møller,Peter Østrup Jensen,Kit G. Madsen,Richard Kerry Phipps,Karen A. Krogfelt,Niels Høiby,Michael Givskov +7 more
TL;DR: It is proposed that the lack of proper wound healing is at least in part caused by inefficient eradication of infecting, opportunistic pathogens, a situation reminiscent of chronic Pseudomonas aeruginosa infections found in patients suffering from cystic fibrosis (CF).
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Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients
Thomas Bjarnsholt,Peter Østrup Jensen,Mark J. Fiandaca,Jette Pedersen,C.R. Hansen,Claus B. Andersen,Tacjana Pressler,Michael Givskov,Niels Høiby +8 more
TL;DR: Investigation of the appearance and location of Pseudomonas aeruginosa in the cystic fibrosis lung and in sputum finds preserved tissues of CF patients who died due to chronic P. aerugInosa lung infection and routine sputums from 77 chronically P. Aerug inosa infected CF patients.