Zhijun Song

TL;DR: A synthetic derivate of natural furanone compounds can act as a potent antagonist of bacterial quorum sensing and inhibited virulence factor expression in a mouse pulmonary infection model.

TL;DR: Bacterial biofilms are resistant to antibiotics, disinfectant chemicals and to phagocytosis and other components of the innate and adaptive inflammatory defense system of the body and they can be treated by chronic suppressive antibiotic therapy.

TL;DR: An efficient treatment ofBiofilm infections needs a well-established multidisciplinary collaboration, which includes removal of the infected foreign bodies, selection of biofilm-active, sensitive and well-penetrating antibiotics, systemic or topical antibiotic administration in high dosage and combinations, and administration of anti-quorum sensing or biofilm dispersal agents.

TL;DR: Two synthetic furanones were tested for their ability to attenuate bacterial virulence in the mouse models of chronic lung infection by targeting bacterial quorum-sensing without directly killing bacteria or inhibiting their growth.

TL;DR: The biofilm mode of growth is the survival strategy of environmental bacteria like Pseudomonas aeruginosa, which occurs in the lungs of chronically infected cystic fibrosis patients, where they protect the bacteria against antibiotics and the immune response.