P
Patrick G. Holt
Researcher at University of Western Australia
Publications - 628
Citations - 43753
Patrick G. Holt is an academic researcher from University of Western Australia. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 103, co-authored 619 publications receiving 41317 citations. Previous affiliations of Patrick G. Holt include Royal Melbourne Hospital & Swansea University.
Papers
More filters
Journal ArticleDOI
Development of allergen-specific T-cell memory in atopic and normal children
TL;DR: The continuation of fetal allergen-specific Th2 responses during infancy is a defining feature of the inductive phase of atopic disease, and is associated with decreased capacity for production of the Th1 cytokine interferon y by atopic neonates.
Journal ArticleDOI
A Polymorphism* in the 5 ′ Flanking Region of the CD14 Gene Is Associated with Circulating Soluble CD14 Levels and with Total Serum Immunoglobulin E
Mauro Baldini,I. Carla Lohman,Marilyn Halonen,Robert P. Erickson,Patrick G. Holt,Fernando D. Martinez +5 more
TL;DR: It is concluded that CD14/-159 plays a significant role in regulating serum sCD14 levels and total serum IgE levels.
Journal Article
Transplacental Priming of the Human Immune System to Environmental Allergens: Universal Skewing of Initial T Cell Responses Toward the Th2 Cytokine Profile
Susan L. Prescott,Claudia Macaubas,Barbara J. Holt,T.B. Smallacombe,Richard Loh,Peter D. Sly,Patrick G. Holt +6 more
TL;DR: These findings imply that the key etiologic factor in atopic disease may not be the initial acquisition of allergen-specific Th2-skewed immunity per se, but instead may be the efficiency of immune deviation mechanisms, which in normal (nonatopic) individuals redirect these fetal immune responses toward the Th1 cytokine phenotype.
Journal ArticleDOI
After asthma: redefining airways diseases
Ian D. Pavord,Richard Beasley,Alvar Agusti,Gary P. Anderson,Elisabeth H. Bel,Guy Brusselle,Guy Brusselle,Paul Cullinan,Adnan Custovic,Francine M. Ducharme,John V. Fahy,Urs Frey,Peter G. Gibson,Peter G. Gibson,Liam G Heaney,Patrick G. Holt,Marc Humbert,Marc Humbert,Clare M. Lloyd,Guy B. Marks,Fernando D. Martinez,Peter D. Sly,Erika von Mutius,Sally E. Wenzel,Heather J. Zar,Andrew Bush +25 more
TL;DR: The only way to make progress in the future is to be much more clear about the meaning of the labels used for asthma and to acknowledge the assumptions associated with them, which are believed to be the most important causes of the stagnation in key clinical outcomes observed in the past 10 years.
Journal ArticleDOI
Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma
Merci Kusel,Nicholas de Klerk,Tatiana Kebadze,Vaike Vohma,Patrick G. Holt,Sebastian L. Johnston,Peter D. Sly +6 more
TL;DR: Data suggest viral infections interact with atopy in infancy to promote later asthma, and protection of “high-risk” children against the effects of severe respiratory infections during infancy may represent an effective strategy for primary asthma prevention.