P
Patrick Nguyen
Researcher at École Normale Supérieure
Publications - 123
Citations - 3520
Patrick Nguyen is an academic researcher from École Normale Supérieure. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 31, co-authored 121 publications receiving 3099 citations. Previous affiliations of Patrick Nguyen include University of Nantes & National Autonomous University of Mexico.
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Journal ArticleDOI
Liver lipid metabolism
Patrick Nguyen,Véronique Leray,Marianne Diez,Samuel Serisier,J. Le Bloc’h,Brigitte Siliart,Henri Dumon +6 more
TL;DR: This review focuses on transcription factors such as sterol-regulatory-element-binding protein-1c and peroxisome proliferator-activated receptor alpha, which promote either hepatic fatty acid synthesis or oxidation.
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Restoration of the integrity of rat caeco-colonic mucosa by resistant starch, but not by fructo-oligosaccharides, in dextran sulfate sodium-induced experimental colitis.
Noëlle M. Moreau,Lucile Martin,Claire Toquet,Christian L. Laboisse,Patrick Nguyen,Brigitte Siliart,Henri Dumon,Martine Champ +7 more
TL;DR: The healing effect of RS confirms the involvement of some types of dietary fibre in inflammatory bowel disease and the ineffectiveness of FOS underlines the importance of the type of dietary substrate.
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Dual Mechanisms for the Fibrate-mediated Repression of Proprotein Convertase Subtilisin/Kexin Type 9
Sanae Kourimate,Cédric Le May,Cédric Langhi,Anne Laure Jarnoux,Khadija Ouguerram,Yassine Zair,Patrick Nguyen,Michel Krempf,Bertrand Cariou,Philippe Costet +9 more
TL;DR: Fibrates simultaneously decreased PCSK9 expression while increasing PC5/6A and furin expression, indicating a broad action of PPARα activation in proprotein convertase-mediated lipid homeostasis and validates the functional relevance of a combined therapy associating PCSK 9 repressors and statins.
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Production rates and metabolism of short-chain fatty acids in the colon and whole body using stable isotopes.
TL;DR: Methods developed for determining the SCFA turnover in animals and in human subjects using stable isotopes provide the basis for a novel strategy to evaluate in vivo, in humans subjects, the production of SCFA in the large intestine.
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Insulin resistance and changes in plasma concentration of TNFalpha, IGF1, and NEFA in dogs during weight gain and obesity.
TL;DR: These metabolic and hormonal impairments are associated with IR, in obese dogs, and could explain, at least in part, the outbreak of this syndrome.