P
Peter J. Tummino
Researcher at GlaxoSmithKline
Publications - 61
Citations - 10372
Peter J. Tummino is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: EZH2 & Histone H3. The author has an hindex of 38, co-authored 58 publications receiving 9470 citations. Previous affiliations of Peter J. Tummino include Janssen Pharmaceutica & Astra.
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Journal ArticleDOI
Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
Alm Richard A,Lo-See L. Ling,Donald T. Moir,Benjamin L. King,Eric D. Brown,Peter Doig,Douglas R. Smith,Brian Noonan,Braydon C. Guild,Boudewijn L. deJonge,Gilles Carmel,Peter J. Tummino,Anthony Caruso,Maria Uria-Nickelsen,Debra M. Mills,Cameron Ives,Rene Gibson,David Merberg,Scott D. Mills,Qin Jiang,Diane E. Taylor,Gerald F. Vovis,Trevor J. Trust +22 more
TL;DR: The overall genomic organization, gene order and predicted proteomes (sets of proteins encoded by the genomes) of the two strains are quite similar, and it is found that H. pylori was believed to exhibit a large degree of genomic and allelic diversity, but this is the first such genomic comparison.
Journal ArticleDOI
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.
Michael T. McCabe,Heidi M. Ott,Gopinath Ganji,Susan Korenchuk,Christine Thompson,Glenn S. Van Aller,Yan Liu,Alan P. Graves,Anthony Della Pietra,Elsie Diaz,Louis V. LaFrance,Mellinger Mark,Celine Duquenne,Xinrong Tian,Ryan G. Kruger,Charles F. McHugh,Martin Brandt,William H. Miller,Dashyant Dhanak,Sharad K. Verma,Peter J. Tummino,Caretha L. Creasy +21 more
TL;DR: GSK126, a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity, decreases global H3K27me3 levels and reactivates silenced PRC2 target genes and markedly inhibits the growth of EzH2 mutant DLBCL xenografts in mice are demonstrated.
Journal ArticleDOI
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.
Chad S Vickers,Paul Hales,Virendar K. Kaushik,Larry Dick,James M. Gavin,Jin Tang,Kevin Godbout,Thomas F. Parsons,Elizabeth Baronas,Frank Y. Hsieh,Susan L. Acton,Michael A. Patane,Andrew J. Nichols,Peter J. Tummino +13 more
TL;DR: The physiological role of ACE2 is elucidated, and its catalytic activity was characterized, and a consensus sequence of: Pro-X (1–3 residues)-Pro-Hydrophobic, where hydrolysis occurs between proline and the hydrophobic amino acid is revealed.
Journal ArticleDOI
Residence time of receptor-ligand complexes and its effect on biological function.
TL;DR: The impact of residence time on the optimization of potential ligands as drugs for human medicine is described and its significance to biological function is described.
Journal ArticleDOI
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
Michael T. McCabe,Alan P. Graves,Gopinath Ganji,Elsie Diaz,Wendy S. Halsey,Yong Jiang,Kimberly N. Smitheman,Heidi M. Ott,Melissa B. Pappalardi,Kimberly E. Allen,Stephanie Chen,Anthony Della Pietra,Edward Dul,Ashley M. Hughes,Seth A. Gilbert,Sara H. Thrall,Peter J. Tummino,Ryan G. Kruger,Martin Brandt,Benjamin J. Schwartz,Caretha L. Creasy +20 more
TL;DR: This mutation highlights the interplay between Y641 and A677 residues in the substrate specificity of EZH2 and identifies another lymphoma patient population that harbors an activating mutation of EzH2.