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Xinrong Tian
Researcher at GlaxoSmithKline
Publications - 28
Citations - 2435
Xinrong Tian is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 6, co-authored 17 publications receiving 2113 citations.
Papers
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Journal ArticleDOI
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.
Michael T. McCabe,Heidi M. Ott,Gopinath Ganji,Susan Korenchuk,Christine Thompson,Glenn S. Van Aller,Yan Liu,Alan P. Graves,Anthony Della Pietra,Elsie Diaz,Louis V. LaFrance,Mellinger Mark,Celine Duquenne,Xinrong Tian,Ryan G. Kruger,Charles F. McHugh,Martin Brandt,William H. Miller,Dashyant Dhanak,Sharad K. Verma,Peter J. Tummino,Caretha L. Creasy +21 more
TL;DR: GSK126, a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity, decreases global H3K27me3 levels and reactivates silenced PRC2 target genes and markedly inhibits the growth of EzH2 mutant DLBCL xenografts in mice are demonstrated.
Journal ArticleDOI
A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.
Helai P. Mohammad,Kimberly N. Smitheman,Chandrashekhar D. Kamat,David Soong,Kelly Federowicz,Glenn S. Van Aller,Jessica L. Schneck,Jeffrey D. Carson,Yan Liu,Michael Butticello,William G. Bonnette,Shelby A. Gorman,Yan Degenhardt,Yuchen Bai,Michael T. McCabe,Melissa B. Pappalardi,Kasparec Jiri,Xinrong Tian,Mcnulty Kenneth C,Rouse Meagan B,Patrick McDevitt,Thau F. Ho,Michelle Crouthamel,Timothy K. Hart,Nestor O. Concha,Charles F. McHugh,William H. Miller,Dashyant Dhanak,Peter J. Tummino,Christopher L. Carpenter,Johnson Neil W,Christine L. Hann,Ryan G. Kruger +32 more
TL;DR: A proliferation screen of cell lines representing a number of tumor types indicated that small cell lung carcinoma (SCLC) is sensitive to LSD1 inhibition, and a subset of SCLC lines and primary samples that undergo growth inhibition in response to GSK2879552 exhibit DNA hypomethylation of a signature set of probes, suggesting this may be used as a predictive biomarker of activity.
Journal ArticleDOI
Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.
Sharad K. Verma,Xinrong Tian,Louis V. LaFrance,Celine Duquenne,Dominic Suarez,Kenneth A. Newlander,Stuart Paul Romeril,Joelle Lorraine Burgess,Seth W. Grant,Brackley James,Alan P. Graves,Daryl A. Scherzer,Art Shu,Christine Thompson,Heidi M. Ott,Glenn S. Van Aller,Carl A. Machutta,Elsie Diaz,Yong Jiang,Johnson Neil W,Steven D. Knight,Ryan G. Kruger,Michael T. McCabe,Dashyant Dhanak,Peter J. Tummino,Caretha L. Creasy,William H. Miller +26 more
TL;DR: This work has identified highly potent, selective, SAM-competitive, and cell-active EZH2 inhibitors, including GSK926 and GSK343, which are small molecule chemical tools that would be useful to further explore the biology of EZh2.
Patent
Cyclopropylamines as lsd1 inhibitors
TL;DR: In this article, the use of cyclopropylamine derivatives for modulation, notably the inhibition of the activity of Lysine-specific demethylase 1 (LSD1), was described.
Journal ArticleDOI
Electronically Engineering Water Resistance in Methane Combustion with an Atomically Dispersed Tungsten on PdO Catalyst.
Zhi-Wen Hou,Lingyun Dai,Jiguang Deng,Guofeng Zhao,Lin Jing,Yueshuai Wang,Xiaohui Yu,Ruyi Gao,Xinrong Tian,Hongxing Dai,Dingsheng Wang,Yuxi Liu +11 more
TL;DR: In this paper , a stepwise strategy for the preparation of atomically dispersed tungsten species at the catalytically active site (Pd nanoparticles) is presented, after an activation process, a Pd-O-W1-like nanocompound is formed on the PdO surface with an atomic scale interface.