Peter P. Bradley

TL;DR: It is demonstrated that MPO can be used as a marker for skin neutrophil content: it is recoverable from skin in soluble form, and is directly related to neutrophIL number.

TL;DR: Data demonstrate that functioning neutrophils can lose approximately half of their MPO, and MPO appears in the extracellular fluid in active form where it is available to participate in a variety of physiologic processes.

TL;DR: This study supports the concept that an elevated immature/total neutrophil ratio can aid in the diagnosis of bacterial infection in the newborn infant and suggests that the degree of elevation may serve as a method for detecting subjects at high risk for depletion of the marrow neutrophils reserves and death from sepsis.

TL;DR: Neutrophil reserve depletion was investigated in groups of premature, 1-day-old and 1-, 2-, and 4-week-old rats by measuring the size and proportion of this pool which was released from the storage compartment when a weight-standardized release stimulus was applied.

TL;DR: These studies show that in renal allograft recipients treated with azathioprine, the prolonged use of trimethoprim-sulfamethoxazole may result in life-threatening hematotoxicity.