P
Philip C Haycock
Researcher at University of Bristol
Publications - 70
Citations - 13030
Philip C Haycock is an academic researcher from University of Bristol. The author has contributed to research in topics: Mendelian randomization & Odds ratio. The author has an hindex of 28, co-authored 63 publications receiving 7277 citations. Previous affiliations of Philip C Haycock include University of Cambridge & Medical Research Council.
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Journal ArticleDOI
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator.
TL;DR: A novel weighted median estimator for combining data on multiple genetic variants into a single causal estimate is presented, which is consistent even when up to 50% of the information comes from invalid instrumental variables.
Journal ArticleDOI
The MR-Base platform supports systematic causal inference across the human phenome
Gibran Hemani,Jie Zheng,Benjamin Elsworth,Kaitlin H Wade,Valeriia Haberland,Denis Baird,Charles Laurin,Stephen Burgess,Jack Bowden,Ryan Langdon,Vanessa Y Tan,James Yarmolinsky,Hashem A Shihab,Nicholas J. Timpson,David M. Evans,David M. Evans,Caroline L Relton,Richard M. Martin,George Davey Smith,Tom R. Gaunt,Philip C Haycock +20 more
TL;DR: MR-Base is a platform that integrates a curated database of complete GWAS results (no restrictions according to statistical significance) with an application programming interface, web app and R packages that automate 2SMR, and includes several sensitivity analyses for assessing the impact of horizontal pleiotropy and other violations of assumptions.
Peer ReviewDOI
Author response: The MR-Base platform supports systematic causal inference across the human phenome
Gibran Hemani,Jie Zheng,Benjamin Elsworth,Kaitlin H Wade,Valeriia Haberland,Denis Baird,Charles Laurin,Stephen Burgess,Jack Bowden,Ryan Langdon,Vanessa Y Tan,James Yarmolinsky,Hashem A Shihab,Nicholas J. Timpson,David M. Evans,David M. Evans,Caroline L Relton,Richard M. Martin,George Davey Smith,Tom R. Gaunt,Philip C Haycock +20 more
Journal ArticleDOI
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis
Jie Zheng,A. Mesut Erzurumluoglu,Benjamin Elsworth,John P. Kemp,Laurence J. Howe,Philip C Haycock,Gibran Hemani,Katherine E. Tansey,Charles Laurin,Early Genetics,Beate St Pourcain,Nicole M. Warrington,Hilary K. Finucane,Hilary K. Finucane,Alkes L. Price,Alkes L. Price,Brendan Bulik-Sullivan,Verneri Anttila,Lavinia Paternoster,Tom R. Gaunt,Tom R. Gaunt,David M. Evans,David M. Evans,Benjamin M. Neale,Benjamin M. Neale +24 more
TL;DR: The proposed LD Hub database and accompanying web interface will ensure maximal uptake of the LD score regression methodology, provide a useful database for the public dissemination of GWAS results, and provide a method for easily screening hundreds of traits for overlapping genetic aetiologies.
Journal ArticleDOI
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis.
Philip C Haycock,Emma E Heydon,Stephen Kaptoge,Adam S. Butterworth,Alexander M. W. Cargill Thompson,Peter Willeit +5 more
TL;DR: In this article, the authors assess the association between leucocyte telomere length and risk of cardiovascular disease using a systematic review and meta-analysis, and show that there is an inverse association between the shortest and longest third of leucomeres length and the risk of coronary heart disease.