R
Richard S. Jope
Researcher at University of Miami
Publications - 261
Citations - 25732
Richard S. Jope is an academic researcher from University of Miami. The author has contributed to research in topics: GSK-3 & Glycogen synthase. The author has an hindex of 77, co-authored 259 publications receiving 24188 citations. Previous affiliations of Richard S. Jope include University of Alabama at Birmingham & University of California, Los Angeles.
Papers
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Journal ArticleDOI
The glamour and gloom of glycogen synthase kinase-3.
TL;DR: Much effort is currently directed towards understanding the functions and control of GSK3, and identifying methods capable of diminishing the deleterious impact of G SK3 in pathological conditions.
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The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
Carol A. Grimes,Richard S. Jope +1 more
TL;DR: GSK3beta has a central role regulating neuronal plasticity, gene expression, and cell survival, and may be a key component of certain psychiatric and neurodegenerative diseases.
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Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases
TL;DR: Glycogen synthase kinase-3 (GSK3) must be particularly adaptable for incorporating new substrates into its repertoire, and the distinct properties of GSK3 that may contribute to its capacity to fulfill its roles in multiple signaling pathways are discussed.
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Toll-like receptor—mediated cytokine production is differentially regulated by glycogen synthase kinase 3
TL;DR: It is reported that glycogen synthase kinase 3 differentially regulates TLR-mediated production of pro- and anti-inflammatory cytokines in mice receiving lipopolysaccharide and mediated protection from endotoxin shock.
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Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics
TL;DR: GSK3 may contribute not only to primary pathologies in these diseases, but also to the associated inflammation, suggesting that GSK3 inhibitors may have multiple effects influencing these conditions.