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Eléonore Beurel
Researcher at University of Alabama at Birmingham
Publications - 22
Citations - 2959
Eléonore Beurel is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: GSK-3 & Glycogen synthase. The author has an hindex of 15, co-authored 15 publications receiving 2713 citations.
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Journal ArticleDOI
Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics
TL;DR: GSK3 may contribute not only to primary pathologies in these diseases, but also to the associated inflammation, suggesting that GSK3 inhibitors may have multiple effects influencing these conditions.
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The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways
Eléonore Beurel,Richard S. Jope +1 more
TL;DR: Studies of this eccentric ability of GSK3 to oppositely influence two types of apoptotic signaling have shed light on important regulatory mechanisms in apoptosis and provide the foundation for designing the rational use of G SK3 inhibitors for therapeutic interventions.
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Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)
TL;DR: GSK3 is a crucial regulator of the balance between pro- and anti-inflammatory cytokine production in both the periphery and the central nervous system, so that GSK3 inhibitors such as lithium can diminish inflammation.
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Deficiency in the Inhibitory Serine-Phosphorylation of Glycogen Synthase Kinase-3 Increases Sensitivity to Mood Disturbances
Abigail M. Polter,Eléonore Beurel,Sufen Yang,Rakesha Garner,Ling Song,Courtney A. Miller,J. David Sweatt,Lori L. McMahon,Alfred A. Bartolucci,Xiaohua Li,Richard S. Jope +10 more
TL;DR: Serine-phosphorylation of GSK3 was reduced during both mood-related behavioral responses in wild-type mouse brain and in blood cells from patients with bipolar disorder, and mice with disabled G SK3 serine- phosphorylation may provide a valuable model to study bipolar disorder.
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GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism
TL;DR: It is indicated that impaired inhibitory regulation of GSK3 in Fmr1 knockout mice may contribute to some socialization deficits and that lithium treatment can ameliorate certain socialization impairments.