Localized Surface Plasmon Resonance Sensors

Modern nanotechnology allows one to scale down various important devices (sensors, chips, fibers, etc.) and thus opens up new horizons for their applications. The efficiency of most of them is based on fundamental physical phenomena, such as transport of wave excitations and resonances. Short propagation distances make phase-coherent processes of waves important. Often the scattering of waves involves propagation along different paths and, as a consequence, results in interference phenomena, where constructive interference corresponds to resonant enhancement and destructive interference to resonant suppression of the transmission. Recently, a variety of experimental and theoretical work has revealed such patterns in different physical settings. The purpose of this review is to relate resonant scattering to Fano resonances, known from atomic physics. One of the main features of the Fano resonance is its asymmetric line profile. The asymmetry originates from a close coexistence of resonant transmission and resonant reflection and can be reduced to the interaction of a discrete (localized) state with a continuum of propagation modes. The basic concepts of Fano resonances are introduced, their geometrical and/or dynamical origin are explained, and theoretical and experimental studies of light propagation in photonic devices, charge transport through quantum dots, plasmon scattering in Josephson-junction networks, and matter-wave scattering in ultracold atom systems, among others are reviewed.

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Fano resonances in nanoscale structures

Sensitive optical biosensors for unlabeled targets: a review.

An overview is presented of the current state-of-the-art in silicon nanophotonic ring resonators. Basic theory of ring resonators is discussed, and applied to the peculiarities of submicron silicon photonic wire waveguides: the small dimensions and tight bend radii, sensitivity to perturbations and the boundary conditions of the fabrication processes. Theory is compared to quantitative measurements. Finally, several of the more promising applications of silicon ring resonators are discussed: filters and optical delay lines, label-free biosensors, and active rings for efficient modulators and even light sources.

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Silicon microring resonators

Recent advances in nanoscience and nanotechnology radically changed the way we diagnose, treat, and prevent various diseases in all aspects of human life. Silver nanoparticles (AgNPs) are one of the most vital and fascinating nanomaterials among several metallic nanoparticles that are involved in biomedical applications. AgNPs play an important role in nanoscience and nanotechnology, particularly in nanomedicine. Although several noble metals have been used for various purposes, AgNPs have been focused on potential applications in cancer diagnosis and therapy. In this review, we discuss the synthesis of AgNPs using physical, chemical, and biological methods. We also discuss the properties of AgNPs and methods for their characterization. More importantly, we extensively discuss the multifunctional bio-applications of AgNPs; for example, as antibacterial, antifungal, antiviral, anti-inflammatory, anti-angiogenic, and anti-cancer agents, and the mechanism of the anti-cancer activity of AgNPs. In addition, we discuss therapeutic approaches and challenges for cancer therapy using AgNPs. Finally, we conclude by discussing the future perspective of AgNPs.

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Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches

Individual nanoparticles in aqueous solution are observed to be attracted to and orbit within the evanescent sensing ring of a Whispering Gallery Mode micro-sensor with only microwatts of driving power. This Carousel trap, caused by attractive optical gradient forces, interfacial interactions, and the circulating momentum flux, considerably enhances the rate of transport to the sensing region, thereby overcoming limitations posed by diffusion on such small area detectors. Resonance frequency fluctuations, caused by the radial Brownian motion of the nanoparticle, reveal the radial trapping potential and the nanoparticle size. Since the attractive forces draw particles to the highest evanescent intensity at the surface, binding steps are found to be uniform.

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Whispering Gallery Mode Carousel--a photonic mechanism for enhanced nanoparticle detection in biosensing.

We describe and demonstrate a physical mechanism that substantially enhances the label-free sensitivity of a whispering-gallery-mode biosensor for the detection of individual nanoparticles in aqueous solution. It involves the interaction of dielectric nanoparticle in an equatorial carousel orbit with a plasmonic nanoparticle bound at the microparticle’s equator. As the dielectric particle parks to hot spots on the plasmonic particle we observe frequency shifts that are enhanced by a factor of 4, consistent with a simple reactive model. Once optimized the enhancement by this mechanism should exceed several orders of magnitude, putting individual protein within reach.

http://research.poly.edu/~sarnold/paper/Pub_095_7823.pdf

Plasmonic enhancement of a whispering-gallery-mode biosensor for single nanoparticle detection

Optical behavior analogous to electromagnetically induced transparency and absorption is observed in experiments using coupled fused-silica microspheres. This behavior results from interference between coresonant whispering-gallery modes of the two spheres. Coupled-resonator-induced transparency and absorption are observed. Which effect is seen depends on the strength of coupling of incident light from a tapered fiber into the first sphere and on the strength of coupling between the two spheres. The observed effects can enhance microresonator performance in various applications.

Induced transparency and absorption in coupled whispering-gallery microresonators

The authors demonstrate a microfluidic dye laser using a liquid core optical ring resonator (LCORR). The LCORR is made of a fused silica capillary with a wall thickness of a few microns. The circular cross section of the capillary forms a ring resonator that supports whispering gallery modes (WGMs) and provides an optical feedback for lasers. Due to the high Q factor of the WGM (107), a low lasing threshold is achieved (1μJ∕mm2). In addition, they show that the laser can be coupled out via a tapered fiber in touch with the LCORR, thus providing a mechanism for easy laser delivery.

S. I. Shopova

Papers

Sensitive optical biosensors for unlabeled targets: a review.

Whispering Gallery Mode Carousel--a photonic mechanism for enhanced nanoparticle detection in biosensing.

Plasmonic enhancement of a whispering-gallery-mode biosensor for single nanoparticle detection

Induced transparency and absorption in coupled whispering-gallery microresonators

Optofluidic ring resonator based dye laser