S
Sander Kersten
Researcher at Wageningen University and Research Centre
Publications - 259
Citations - 27507
Sander Kersten is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Adipose tissue & Peroxisome proliferator-activated receptor. The author has an hindex of 79, co-authored 246 publications receiving 23985 citations. Previous affiliations of Sander Kersten include University of Lausanne & Leiden University Medical Center.
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Journal ArticleDOI
Roles of PPARs in health and disease.
TL;DR: The latest developments in the PPAR field are presented, with particular emphasis on the physiological function ofPPARs during various nutritional states, and the possible role of PPARs in several chronic diseases.
Journal ArticleDOI
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Sander Kersten,Josiane Seydoux,Jeffrey M. Peters,Frank J. Gonzalez,Béatrice Desvergne,Walter Wahli +5 more
TL;DR: It is shown that to accommodate the increased requirement for hepatic fatty acid oxidation, PPAR α mRNA is induced during fasting in wildtype mice, indicating that PPARα plays a pivotal role in the management of energy stores during fasting.
Journal ArticleDOI
Peroxisome proliferator-activated receptor α target genes
TL;DR: In this article, the involvement of PPARalpha in peroxisomal and mitochondrial fatty acid oxidation, microsomal fatty acid hydroxylation, lipoprotein, bile and amino acid metabolism, glucose homeostasis, biotransformation, inflammation control, hepato-carcinogenesis and other pathways, through a detailed analysis of the different known or putative PPARα target genes.
Journal ArticleDOI
Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
Silvie Timmers,Ellen Konings,L. Bilet,Riekelt H. Houtkooper,Tineke van de Weijer,Gijs H. Goossens,Joris Hoeks,Sophie E. van der Krieken,Dongryeol Ryu,Sander Kersten,Esther Moonen-Kornips,Matthijs K. C. Hesselink,Iris Kunz,Vera B. Schrauwen-Hinderling,Ellen E. Blaak,Johan Auwerx,Patrick Schrauwen +16 more
TL;DR: It is demonstrated that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.
Journal ArticleDOI
Peroxisome Proliferator-Activated Receptor Alpha Target Genes
TL;DR: An overview of the involvement of PPARα in lipid metabolism and other pathways through a detailed analysis of the different known or putative PPAR α target genes is presented.