S
Sara Akhavanfard
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 13
Citations - 5674
Sara Akhavanfard is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Wilms' tumor & Germline. The author has an hindex of 10, co-authored 13 publications receiving 5070 citations. Previous affiliations of Sara Akhavanfard include Cleveland Clinic & Case Western Reserve University.
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Journal ArticleDOI
Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors
Lecia V. Sequist,Belinda A. Waltman,Dora Dias-Santagata,Subba R. Digumarthy,Alexa B. Turke,Panos Fidias,Kristin Bergethon,Alice T. Shaw,Scott N. Gettinger,Arjola K. Cosper,Sara Akhavanfard,Rebecca S. Heist,Jennifer S. Temel,James G. Christensen,John C. Wain,Thomas J. Lynch,Kathy Vernovsky,Eugene J. Mark,Michael Lanuti,A. John Iafrate,Mari Mino-Kenudson,Jeffrey A. Engelman +21 more
TL;DR: Detailed genetic and histological analysis of 37 patients with drug-resistant non–small cell lung cancers carrying EGFR mutations provides new insights into the shifting sands of drug resistance evolution in lung cancers and suggests that serial biopsies may be essential in the quest to reverse or even prevent the development ofdrug resistance.
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Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC
Alexa B. Turke,Kreshnik Zejnullahu,Yi-Long Wu,Youngchul Song,Dora Dias-Santagata,Eugene Lifshits,Luca Toschi,Andrew H. Rogers,Tony Mok,Lecia V. Sequist,Neal I. Lindeman,Carly Murphy,Sara Akhavanfard,Beow Y. Yeap,Yun Xiao,Yun Xiao,Marzia Capelletti,A. John Iafrate,Charles Lee,James G. Christensen,Jeffrey A. Engelman,Pasi A. Jänne +21 more
TL;DR: Using high-throughput FISH analyses in both cell lines and in patients with lung cancer, the potential to prospectively identify treatment naive, patients with EGFR-mutant lung cancer who will benefit from initial combination therapy is highlighted.
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Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma
Matija Snuderl,Ladan Fazlollahi,Long P. Le,Mai Nitta,Boryana H. Zhelyazkova,Christian Davidson,Sara Akhavanfard,Daniel P. Cahill,Kenneth Aldape,Rebecca A. Betensky,David N. Louis,A. John Iafrate +11 more
TL;DR: An example of genetic heterogeneity in human malignant brain tumors in which multiple closely related driver genes are amplified and activated simultaneously in adjacent intermingled cells is presented.
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Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.
David T. Ting,Doron Lipson,Suchismita Paul,Brian W. Brannigan,Sara Akhavanfard,Erik J. Coffman,Gianmarco Contino,Vikram Deshpande,A. John Iafrate,Stan Letovsky,Miguel Rivera,Nabeel Bardeesy,Shyamala Maheswaran,Daniel A. Haber +13 more
TL;DR: The overexpression of satellite transcripts in cancer may reflect global alterations in heterochromatin silencing and could potentially be useful as a biomarker for cancer detection.
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Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine
Dora Dias-Santagata,Sara Akhavanfard,Serena S. David,Kathy Vernovsky,Georgiana Kuhlmann,Susan L. Boisvert,Hannah Stubbs,Ultan McDermott,Jeffrey Settleman,Eunice L. Kwak,Jeffrey W. Clark,Steven J. Isakoff,Lecia V. Sequist,Jeffrey A. Engelman,Thomas J. Lynch,Daniel A. Haber,David N. Louis,Leif W. Ellisen,Darrell R. Borger,A. John Iafrate +19 more
TL;DR: A highly sensitive multiplexed clinical assay that performs very well with nucleic acid derived from formalin fixation and paraffin embedding tissue, and tests for 120 previously described mutations in 13 cancer genes, establishes a platform for real‐time targeted genotyping that can be widely adopted.