J
Jeffrey Settleman
Researcher at Genentech
Publications - 190
Citations - 40059
Jeffrey Settleman is an academic researcher from Genentech. The author has contributed to research in topics: GTPase & Cancer. The author has an hindex of 78, co-authored 189 publications receiving 37539 citations. Previous affiliations of Jeffrey Settleman include Yale University & Harvard University.
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Journal ArticleDOI
Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer
Eunice L. Kwak,Yung-Jue Bang,D. Ross Camidge,Alice T. Shaw,Benjamin Solomon,Robert G. Maki,Sai-Hong Ignatius Ou,Bruce J. Dezube,Pasi A. Jänne,Daniel B. Costa,Marileila Varella-Garcia,Woo-Ho Kim,Thomas J. Lynch,Panos Fidias,Hannah Stubbs,Jeffrey A. Engelman,Lecia V. Sequist,Weiwei Tan,Leena Gandhi,Mari Mino-Kenudson,Greg C. Wei,S. Martin Shreeve,Mark J. Ratain,Jeffrey Settleman,James G. Christensen,Daniel A. Haber,Keith D. Wilner,Ravi Salgia,Geoffrey I. Shapiro,Jeffrey W. Clark,A. John Iafrate +30 more
TL;DR: The inhibition of ALK in lung tumors with the ALK rearrangement resulted in tumor shrinkage or stable disease in most patients, and the drug resulted in grade 1 or 2 gastrointestinal side effects.
Journal ArticleDOI
Epidermal growth factor receptor mutations in lung cancer
TL;DR: 'oncogenic shock' is described as a mechanistic explanation for the apoptosis that follows the acute treatment of susceptible cells with kinase inhibitors, essential to the successful use of targeted therapies in common epithelial cancers.
Journal ArticleDOI
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
TL;DR: This review will provide potential mechanistic explanations for the association between EMT induction and the emergence of CSCs, and highlight recent studies implicating the function of TGF-β-regulated noncoding RNAs in driving EMT and promoting CSC self-renewal.
Journal ArticleDOI
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
Daniel J. Klionsky,Hagai Abeliovich,Patrizia Agostinis,Devendra K. Agrawal,Gjumrakch Aliev,David S. Askew,Misuzu Baba,Eric H. Baehrecke,Ben A. Bahr,Andrea Ballabio,Bruce A. Bamber,Diane C. Bassham,Ettore Bergamini,Xiaoning Bi,Martine Biard-Piechaczyk,Janice S. Blum,Dale E. Bredesen,Jeffrey L. Brodsky,John H. Brumell,Ulf T. Brunk,Wilfried Bursch,Nadine Camougrand,Eduardo Cebollero,Francesco Cecconi,Yingyu Chen,Lih-Shen Chin,Augustine M.K. Choi,Charleen T. Chu,Jongkyeong Chung,Peter G.H. Clarke,Robert S. B. Clark,Steven Clarke,Corinne Clavé,John L. Cleveland,Patrice Codogno,María Isabel Colombo,Ana Coto-Montes,James M. Cregg,Ana Maria Cuervo,Jayanta Debnath,Francesca Demarchi,Patrick B. Dennis,Phillip A. Dennis,Vojo Deretic,Rodney J. Devenish,Federica Di Sano,J. Fred Dice,Marian DiFiglia,Savithramma P. Dinesh-Kumar,Clark W. Distelhorst,Mojgan Djavaheri-Mergny,Frank C. Dorsey,Wulf Dröge,Michel Dron,William A. Dunn,Michael Duszenko,N. Tony Eissa,Zvulun Elazar,Audrey Esclatine,Eeva-Liisa Eskelinen,László Fésüs,Kim D. Finley,José M. Fuentes,Juan Fueyo,Kozo Fujisaki,Brigitte Galliot,Fen-Biao Gao,David A. Gewirtz,Spencer B. Gibson,Antje Gohla,Alfred L. Goldberg,Ramon Gonzalez,Cristina González-Estévez,Sharon M. Gorski,Roberta A. Gottlieb,Dieter Häussinger,You-Wen He,Kim A. Heidenreich,Joseph A. Hill,Maria Høyer-Hansen,Xun Hu,Wei-Pang Huang,Akiko Iwasaki,Marja Jäättelä,William T. Jackson,Xuejun Jiang,Shengkan Jin,Terje Johansen,Jae U. Jung,Motoni Kadowaki,Chanhee Kang,Ameeta Kelekar,David Kessel,Jan A.K.W. Kiel,Pyo Kim Hong,Adi Kimchi,Timothy J. Kinsella,Kirill Kiselyov,Katsuhiko Kitamoto,Erwin Knecht,Masaaki Komatsu,Eiki Kominami,Seiji Kondo,Attila L. Kovács,Guido Kroemer,Chia Yi Kuan,Rakesh Kumar,Mondira Kundu,Jacques Landry,Marianne M. Laporte,Weidong Le,Huan Yao Lei,Michael J. Lenardo,Beth Levine,Andrew P. Lieberman,Kah-Leong Lim,Fu-Cheng Lin,Willisa Liou,Leroy F. Liu,Gabriel Lopez-Berestein,Carlos López-Otín,Bo Lu,Kay F. Macleod,Walter Malorni,Wim Martinet,Ken Matsuoka,Josef Mautner,Alfred J. Meijer,Alicia Meléndez,Paul A.M. Michels,Giovanni Miotto,Wilhelm P. Mistiaen,Noboru Mizushima,Baharia Mograbi,Iryna Monastyrska,Michael Moore,Paula I. Moreira,Yuji Moriyasu,Tomasz Motyl,Christian Münz,Leon Murphy,Naweed I. Naqvi,Thomas P. Neufeld,Ichizo Nishino,Ralph A. Nixon,Takeshi Noda,Bernd Nürnberg,Michinaga Ogawa,Nancy L. Oleinick,Laura J. Olsen,Bulent Ozpolat,Shoshana Paglin,Glen E. Palmer,Issidora S. Papassideri,Miles Parkes,David H. Perlmutter,George Perry,Mauro Piacentini,Ronit Pinkas-Kramarski,Mark Prescott,Tassula Proikas-Cezanne,Nina Raben,Abdelhaq Rami,Fulvio Reggiori,Bärbel Rohrer,David C. Rubinsztein,Kevin M. Ryan,Junichi Sadoshima,Hiroshi Sakagami,Yasuyoshi Sakai,Marco Sandri,Chihiro Sasakawa,Miklós Sass,Claudio Schneider,Per Ottar Seglen,Oleksandr Seleverstov,Jeffrey Settleman,John J. Shacka,Irving M. Shapiro,Andrei A. Sibirny,Elaine C.M. Silva-Zacarin,Hans-Uwe Simon,Crisfiano Simone,Anne Simonsen,Mark A. Smith,Katharina Spanel-Borowski,Vickram Srinivas,Meredith A. Steeves,Harald Stenmark,Per E. Stromhaug,Carlos S. Subauste,Seiichiro Sugimoto,David Sulzer,Toshihiko Suzuki,Michele S. Swanson,Ira Tabas,Fumihiko Takeshita,Nicholas J. Talbot,Zsolt Tallóczy,Keiji Tanaka,Kozo Tanaka,Isei Tanida,Graham S. Taylor,J. Paul Taylor,Alexei Terman,Gianluca Tettamanti,Craig B. Thompson,Michael Thumm,Aviva M. Tolkovsky,Sharon A. Tooze,Ray Truant,Lesya V. Tumanovska,Yasuo Uchiyama,Takashi Ueno,Néstor L. Uzcátegui,Ida J. van der Klei,Eva C. Vaquero,Tibor Vellai,Michael W. Vogel,Hong Gang Wang,Paul Webster,John W. Wiley,Zhijun Xi,Gutian Xiao,Joachim Yahalom,Jin Ming Yang,George S. Yap,Xiao Ming Yin,Tamotsu Yoshimori,Li Yu,Zhenyu Yue,Michisuke Yuzaki,Olga Zabirnyk,Xiaoxiang Zheng,Xiongwei Zhu,Russell L. Deter +235 more
TL;DR: A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
Journal ArticleDOI
Systematic identification of genomic markers of drug sensitivity in cancer cells
Mathew J. Garnett,Elena J. Edelman,Sonja J. Heidorn,Christopher Greenman,Christopher Greenman,Anahita Dastur,King Wai Lau,Patricia Greninger,I. Richard Thompson,Xi Luo,Jorge Soares,Qingsong Liu,Francesco Iorio,Francesco Iorio,Didier Surdez,Li Chen,Randy J. Milano,Graham R. Bignell,Ah Ting Tam,Helen Davies,Jesse A. Stevenson,Syd Barthorpe,Stephen R. Lutz,Fiona Kogera,Karl P. Lawrence,Anne McLaren-Douglas,Xeni Mitropoulos,Tatiana Mironenko,Helen Thi,Laura Richardson,Wenjun Zhou,F Jewitt,Tinghu Zhang,Patrick O’Brien,Jessica L. Boisvert,Stacey Price,Wooyoung Hur,Wanjuan Yang,Xianming Deng,Adam Butler,Hwan Geun Choi,Jae Won Chang,José Baselga,Ivan Stamenkovic,Jeffrey A. Engelman,Sreenath V. Sharma,Sreenath V. Sharma,Olivier Delattre,Julio Saez-Rodriguez,Nathanael S. Gray,Jeffrey Settleman,P. Andrew Futreal,Daniel A. Haber,Daniel A. Haber,Michael R. Stratton,Sridhar Ramaswamy,Ultan McDermott,Cyril H. Benes +57 more
TL;DR: It was found that mutated cancer genes were associated with cellular response to most currently available cancer drugs, and systematic pharmacogenomic profiling in cancer cell lines provides a powerful biomarker discovery platform to guide rational cancer therapeutic strategies.