Sarah Bowden

TL;DR: The presence of CD8+ T cells in breast cancer is associated with a significant reduction in the relative risk of death from disease in both the ER-negative and ER-positive HER2-positive subtypes and may improve risk stratification in Breast cancer patients classified into these subtypes.

TL;DR: ATTom confirms that, in ER+ disease, continuing tamoxifen to year 10 rather than just to year 5 produces further reductions in recurrence, from year 7 onward, and breast cancer mortality after year 10.

TL;DR: The background and development of 'The low risk' DCIS trial (LORIS), a phase III trial of surgery versus active monitoring, will determine if it is appropriate to manage women with screen detected or asymptomatic, low grade and intermediate grade DCIS with low grade features, by active monitoring rather than by surgical treatment.

TL;DR: PD-L1 inhibition may benefit the 19% of patients with basal-like tumours in which the protein is expressed and is correlated with infiltrating lymphocytes, according to a nominally significant association between PD-L 1 and improved disease-specific survival.

TL;DR: Data demonstrate that pharmacologically distinct channels respond to distinct types of mechanical stimuli and suggest that mechanically activated sustained currents underlie noxious mechanosensation and provides a novel diagnostic tool for the molecular definition of channels involved in hearing and pressure-evoked pain.