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Shinichi Toyooka
Researcher at Okayama University
Publications - 534
Citations - 23323
Shinichi Toyooka is an academic researcher from Okayama University. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 65, co-authored 476 publications receiving 21121 citations. Previous affiliations of Shinichi Toyooka include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
Tetsuya Mitsudomi,Satoshi Morita,Yasushi Yatabe,Shunichi Negoro,Isamu Okamoto,Junji Tsurutani,Takashi Seto,Miyako Satouchi,Hirohito Tada,Tomonori Hirashima,Kazuhiro Asami,Nobuyuki Katakami,Minoru Takada,Hiroshige Yoshioka,Kazuhiko Shibata,Shinzoh Kudoh,Eiji Shimizu,Hiroshi Saito,Shinichi Toyooka,Kazuhiko Nakagawa,Masahiro Fukuoka +20 more
TL;DR: In this article, an open label, phase 3 study (WJTOG3405) with recruitment between March 31, 2006, and June 22, 2009, at 36 centers in Japan was conducted.
Journal ArticleDOI
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
Hisayuki Shigematsu,Hisayuki Shigematsu,Li Lin,Takao Takahashi,Masaharu Nomura,Makoto Suzuki,Ignacio I. Wistuba,Kwun M. Fong,Huei Lee,Shinichi Toyooka,Nobuyoshi Shimizu,Takehiko Fujisawa,Ziding Feng,Jack A. Roth,Joachim Herz,John D. Minna,Adi F. Gazdar +16 more
TL;DR: EGFR TK domain mutations are the first molecular change known to occur specifically in never smokers, and can lead to lung cancer pathogenesis.
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Epigenetic Inactivation of RASSF1A in Lung and Breast Cancers and Malignant Phenotype Suppression
David Burbee,Eva Forgacs,Sabine Zöchbauer-Müller,Latha Shivakumar,Kwun M. Fong,Boning Gao,Dwight Randle,Masashi Kondo,Arvind K. Virmani,Scott A. Bader,Yoshitaka Sekido,Farida Latif,Sara Milchgrub,Shinichi Toyooka,Adi F. Gazdar,Michael I. Lerman,Eugene R. Zabarovsky,Michael A. White,John D. Minna +18 more
TL;DR: RASSF1A is a potential tumor suppressor gene that undergoes epigenetic inactivation in lung and breast cancers through hypermethylation of its promoter region and is associated with impaired patient survival.
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Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
Hisayuki Shigematsu,Hisayuki Shigematsu,Takao Takahashi,Masaharu Nomura,Kuntal Majmudar,Makoto Suzuki,Huei Lee,Ignacio I. Wistuba,Kwun M. Fong,Shinichi Toyooka,Nobuyoshi Shimizu,Takehiko Fujisawa,John D. Minna,Adi F. Gazdar +13 more
TL;DR: The remarkable similarities of mutations in EGFR and HER2 genes involving tumor type and subtype, mutation type, gene location, and specific patient subpopulations targeted are unprecedented and suggest similar etiologic factors.
Journal Article
The Relationship between Epidermal Growth Factor Receptor Mutations and Clinicopathologic Features in Non–Small Cell Lung Cancers
Masaki Tokumo,Shinichi Toyooka,Katsuyuki Kiura,Hisayuki Shigematsu,Kunitoshi Tomii,Motoi Aoe,Kouichi Ichimura,Toshihide Tsuda,Masaaki Yano,Kazunori Tsukuda,Masahiro Tabata,Hiroshi Ueoka,Mitsune Tanimoto,Hiroshi Date,Adi F. Gazdar,Nobuyoshi Shimizu +15 more
TL;DR: In this article, the authors investigated the relationship between EGFR mutation and clinicopathologic features and found that EGFR mutations were significantly related to histology and smoke exposure and were a strong predictive factor for gefitinib responsiveness in NSCLC.