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Shunsuke Kimura
Researcher at Keio University
Publications - 52
Citations - 4820
Shunsuke Kimura is an academic researcher from Keio University. The author has contributed to research in topics: Microfold cell & Antigen. The author has an hindex of 22, co-authored 48 publications receiving 4048 citations. Previous affiliations of Shunsuke Kimura include Osaka University & Nagoya City University.
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Journal ArticleDOI
Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged LC3
TL;DR: Using this method, evidence that overexpression of a dominant negative form of Rab7 prevented the fusion of autophagosomes with lysosomes is provided, suggesting that Rab7 is involved in this step.
Journal ArticleDOI
Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.
Koji Hase,Kazuya Kawano,Tomonori Nochi,Gemilson Soares Pontes,Shinji Fukuda,Masashi Ebisawa,Kazunori Kadokura,Toru Tobe,Yumiko Fujimura,Sayaka Kawano,Atsuko Yabashi,Satoshi Waguri,Gaku Nakato,Shunsuke Kimura,Takaya Murakami,Mitsutoshi Iimura,Kimiyo Hamura,Shin Ichi Fukuoka,Anson W. Lowe,Kikuji Itoh,Hiroshi Kiyono,Hiroshi Ohno +21 more
TL;DR: GP2 is a previously unrecognized transcytotic receptor on M cells for type-I-piliated bacteria and is a prerequisite for the mucosal immune response to these bacteria, which could provide a new target for the development of M-cell-targeted mucosal vaccines.
Journal ArticleDOI
Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes.
TL;DR: The real-time behavior of microtubule-associated protein light chain 3 (LC3), which localizes to autophagosomes, is observed, and it is shown that autphagosomes move in a micro Tubule- and dynein-dynactin motor complex-dependent manner.
Journal ArticleDOI
M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex.
Koji Hase,Shunsuke Kimura,Hiroyuki Takatsu,Masumi Ohmae,Sayaka Kawano,Hiroshi Kitamura,Masatoshi Ito,Hiroshi Watarai,C. Clayton Hazelett,Charles Yeaman,Hiroshi Ohno +10 more
TL;DR: It is reported that a mammalian protein, M-Sec, induces de novo formation of numerous membrane protrusions extending from the plasma membrane, some of which tether onto adjacent cells and subsequently form TNT-like structures.
Book ChapterDOI
Monitoring autophagy in mammalian cultured cells through the dynamics of LC3.
TL;DR: In this chapter, several methods that rely on the analysis of LC3, a versatile marker protein of autophagic structures in mammalian cultured cells, are introduced to provide a relatively easy assessment ofAutophagy.