Shyamala Ganesan

TL;DR: In this paper, the authors reviewed the regulation of components of barrier function with respect to chronic airway diseases and showed that impairment of one or more of these essential components may increase susceptibility to infection and promote exaggerated and prolonged innate immune responses to environmental factors including allergens and pathogens resulting in chronic inflammation.

TL;DR: Airway epithelial cells from patients with COPD show higher baseline levels of cytokine expression and increased susceptibility to RV infection, despite an increased IFN response.

TL;DR: Results suggest that quercetin inhibits RV endocytosis and replication in airway epithelial cells at multiple stages of the RV life cycle, which decreases expression of pro-inflammatory cytokines and improves lung function in RV-infected mice.

TL;DR: Quercetin prevents progression of emphysema in elastase/LPS-treated mice by reducing oxidative stress, lung inflammation and expression of MMP9 and MMP12 in vivo and in vitro.

TL;DR: It is concluded that Rac1-dependent NOX1 activity is required for RV- or poly(I:C)-induced ROS generation, which in turn disrupts the barrier function of polarized airway epithelia, and suggests that dsRNA generated during RV replication is sufficient to disrupt barrier function.