U
Uma S. Sajjan
Researcher at University of Michigan
Publications - 24
Citations - 1637
Uma S. Sajjan is an academic researcher from University of Michigan. The author has contributed to research in topics: Rhinovirus & Inflammation. The author has an hindex of 20, co-authored 24 publications receiving 1421 citations.
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Journal ArticleDOI
Barrier function of airway tract epithelium
TL;DR: In this paper, the authors reviewed the regulation of components of barrier function with respect to chronic airway diseases and showed that impairment of one or more of these essential components may increase susceptibility to infection and promote exaggerated and prolonged innate immune responses to environmental factors including allergens and pathogens resulting in chronic inflammation.
Journal ArticleDOI
Quercetin inhibits rhinovirus replication in vitro and in vivo
Shyamala Ganesan,Andrea N. Faris,Adam T. Comstock,Qiong Wang,Suparna Nanua,Marc B. Hershenson,Uma S. Sajjan +6 more
TL;DR: Results suggest that quercetin inhibits RV endocytosis and replication in airway epithelial cells at multiple stages of the RV life cycle, which decreases expression of pro-inflammatory cytokines and improves lung function in RV-infected mice.
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Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells.
Jun Young Hong,J. Kelley Bentley,Yutein Chung,Jing Lei,Jessica Steenrod,Qiang Chen,Uma S. Sajjan,Marc B. Hershenson +7 more
TL;DR: It is suggested that early-life viral infection could contribute to asthma development by provoking age-dependent, IL-25-driven type 2 immune responses.
Journal ArticleDOI
Efficacy of Bacteriophage Therapy in a Model of Burkholderia cenocepacia Pulmonary Infection
Lisa A. Carmody,Jason J. Gill,Elizabeth J. Summer,Uma S. Sajjan,Carlos F. Gonzalez,Ryland F. Young,John J. LiPuma +6 more
TL;DR: Systemic phage administration was more effective than inhalational administration, suggesting that circulating phages have better access to bacteria in lungs than do topical phages.
Journal ArticleDOI
Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression
Shyamala Ganesan,Andrea N. Faris,Adam T. Comstock,Sangbrita Chattoraj,Asamanja Chattoraj,John R. Burgess,Jeffrey L. Curtis,Fernando J. Martinez,Suzanna M. Zick,Marc B. Hershenson,Uma S. Sajjan +10 more
TL;DR: Quercetin prevents progression of emphysema in elastase/LPS-treated mice by reducing oxidative stress, lung inflammation and expression of MMP9 and MMP12 in vivo and in vitro.