S
Sigrid A. Langhans
Researcher at Alfred I. duPont Hospital for Children
Publications - 34
Citations - 2078
Sigrid A. Langhans is an academic researcher from Alfred I. duPont Hospital for Children. The author has contributed to research in topics: Na+/K+-ATPase & Self-healing hydrogels. The author has an hindex of 15, co-authored 30 publications receiving 1427 citations. Previous affiliations of Sigrid A. Langhans include Nemours Foundation & University of Delaware.
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Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning.
TL;DR: Common approaches to 3D culture are reviewed, the significance of 3D cultures in drug resistance and drug repositioning is discussed and some of the challenges of applying 3D cell cultures to high-throughput drug discovery are addressed.
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Cancer as a channelopathy: ion channels and pumps in tumor development and progression
Alisa Litan,Sigrid A. Langhans +1 more
TL;DR: Recent research into the role of ion pumps and ion channels in cell migration and adhesion, and how they may contribute to tumor development is described.
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Peptide hydrogels - versatile matrices for 3D cell culture in cancer medicine
TL;DR: The biochemical functionalization of peptide hydrogels and how this functionalization, coupled with desired hydrogel material characteristics, affects tumor cell behavior in 3D culture is discussed.
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Crosstalk of Oncogenic Signaling Pathways during Epithelial–Mesenchymal Transition
TL;DR: Functional redundancies allow cells to undergo EMT even if key transcriptional regulators are lacking, but these same redundancies also make these pathways particularly susceptible to gain-of-function mutations or constitutive signal activation; the “forced” transition toward either a mesenchymal or epithelial phenotype.
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Transcriptional regulators of Na,K-ATPase subunits.
Zhiqin Li,Sigrid A. Langhans +1 more
TL;DR: This review aims at summarizing the best-characterized transcription regulators that modulate Na,K-ATPase subunit levels and discusses transcription factors that are associated with epithelial-mesenchymal transition, a crucial step in the progression of many tumors to malignant disease.