S
Simon Mallal
Researcher at Vanderbilt University Medical Center
Publications - 432
Citations - 28417
Simon Mallal is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Human leukocyte antigen & Abacavir. The author has an hindex of 74, co-authored 400 publications receiving 24687 citations. Previous affiliations of Simon Mallal include University of Western Australia & Princess Margaret Hospital for Children.
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Journal ArticleDOI
HLA-B*5701 Screening for Hypersensitivity to Abacavir
Simon Mallal,Elizabeth J. Phillips,Giampiero Carosi,Jean-Michel Molina,Cassy Workman,Janez Tomazic,Eva Jägel-Guedes,Sorin Rugină,Oleg Kozyrev,Juan Flores Cid,Phillip Hay,David Nolan,Sara Hughes,Arlene R Hughes,Susanna Ryan,Nicholas Fitch,D. Thorborn,Alastair Benbow +17 more
TL;DR: HLA-B*5701 screening reduced the risk of hypersensitivity reaction to abacavir and showed that a pharmacogenetic test can be used to prevent a specific toxic effect of a drug.
Journal ArticleDOI
Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
Simon Mallal,Simon Mallal,David Nolan,C.S. Witt,C.S. Witt,G. Masel,G. Masel,Annalise M Martin,Corey Moore,D.C. Sayer,D.C. Sayer,A. Castley,Cyril D. S. Mamotte,Cyril D. S. Mamotte,D. Maxwell,Ian James,Frank T. Christiansen,Frank T. Christiansen +17 more
TL;DR: In this population of HIV-1-positive individuals, withholding abacavir in those with HLA-B*5701, H LA-DR7, and Hla-DQ3 should reduce the prevalence of hypersensitivity from 9% to 2.5% without inappropriately denying abacvir to any patient.
Journal ArticleDOI
A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1
Jacques Fellay,Kevin V. Shianna,Dongliang Ge,Sara Colombo,Bruno Ledergerber,Michael E. Weale,Kunlin Zhang,Curtis Gumbs,Antonella Castagna,Andrea Cossarizza,Alessandro Cozzi-Lepri,Andrea De Luca,Philippa Easterbrook,P Francioli,Simon Mallal,Javier Martinez-Picado,José M. Miró,Niels Obel,Jason Smith,Josiane Wyniger,Patrick Descombes,Stylianos E. Antonarakis,Norman L. Letvin,Andrew J. McMichael,Barton F. Haynes,Amalio Telenti,David Goldstein +26 more
TL;DR: Using a whole-genome association strategy, polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection are identified.
Journal ArticleDOI
Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans.
Jose Mateus,Alba Grifoni,Alison Tarke,John Sidney,Sydney I. Ramirez,Sydney I. Ramirez,Jennifer M. Dan,Jennifer M. Dan,Zoe C Burger,Stephen A. Rawlings,Davey M. Smith,Elizabeth J. Phillips,Simon Mallal,Marshall Lammers,Paul Rubiro,Lorenzo Quiambao,Aaron Sutherland,Esther Dawen Yu,Ricardo da Silva Antunes,Jason A. Greenbaum,April Frazier,Alena J. Markmann,Lakshmanane Premkumar,Aravinda M. de Silva,Bjoern Peters,Bjoern Peters,Shane Crotty,Shane Crotty,Alessandro Sette,Alessandro Sette,Daniela Weiskopf +30 more
TL;DR: A range of preexisting memory CD4+ T cells that are cross-reactive with comparable affinity to SARS-CoV-2 and the common cold coronaviruses human coronavirus (HCoV)-OC43, H coV-229E, H CoV-NL63, and HCov-HKU1 are demonstrated.
Journal ArticleDOI
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
Photini Kiepiela,Alasdair Leslie,Isobella Honeyborne,Danni Ramduth,Christina F. Thobakgale,Senica Chetty,Prinisha Rathnavalu,Corey Moore,Katja Pfafferott,Louise Hilton,Peter Zimbwa,Sarah Moore,Todd M. Allen,Christian Brander,Marylyn M. Addo,Marcus Altfeld,Ian James,Simon Mallal,Michael Bunce,Linda Barber,James J. Szinger,James J. Szinger,Cheryl L. Day,Paul Klenerman,James I. Mullins,Bette T. Korber,Bette T. Korber,Hoosen M. Coovadia,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Philip J. R. Goulder,Philip J. R. Goulder +32 more
TL;DR: Analysis of class I restricted CD8+ T-cell responses against human immunodeficiency virus (HIV-1) indicates that the principal focus of HIV-specific activity is at the HLA-B locus, consistent with the observation that B alleles evolve more rapidly than A alleles.