I
Ian James
Researcher at Murdoch University
Publications - 220
Citations - 10983
Ian James is an academic researcher from Murdoch University. The author has contributed to research in topics: Human leukocyte antigen & Population. The author has an hindex of 43, co-authored 210 publications receiving 10228 citations. Previous affiliations of Ian James include King Edward Memorial Hospital & University of Western Australia.
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Journal ArticleDOI
Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
Simon Mallal,Simon Mallal,David Nolan,C.S. Witt,C.S. Witt,G. Masel,G. Masel,Annalise M Martin,Corey Moore,D.C. Sayer,D.C. Sayer,A. Castley,Cyril D. S. Mamotte,Cyril D. S. Mamotte,D. Maxwell,Ian James,Frank T. Christiansen,Frank T. Christiansen +17 more
TL;DR: In this population of HIV-1-positive individuals, withholding abacavir in those with HLA-B*5701, H LA-DR7, and Hla-DQ3 should reduce the prevalence of hypersensitivity from 9% to 2.5% without inappropriately denying abacvir to any patient.
Journal ArticleDOI
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
Photini Kiepiela,Alasdair Leslie,Isobella Honeyborne,Danni Ramduth,Christina F. Thobakgale,Senica Chetty,Prinisha Rathnavalu,Corey Moore,Katja Pfafferott,Louise Hilton,Peter Zimbwa,Sarah Moore,Todd M. Allen,Christian Brander,Marylyn M. Addo,Marcus Altfeld,Ian James,Simon Mallal,Michael Bunce,Linda Barber,James J. Szinger,James J. Szinger,Cheryl L. Day,Paul Klenerman,James I. Mullins,Bette T. Korber,Bette T. Korber,Hoosen M. Coovadia,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Philip J. R. Goulder,Philip J. R. Goulder +32 more
TL;DR: Analysis of class I restricted CD8+ T-cell responses against human immunodeficiency virus (HIV-1) indicates that the principal focus of HIV-specific activity is at the HLA-B locus, consistent with the observation that B alleles evolve more rapidly than A alleles.
Journal ArticleDOI
Evidence of HIV-1 Adaptation to HLA-Restricted Immune Responses at a Population Level
Corey Moore,Mina John,Ian James,Frank T. Christiansen,Frank T. Christiansen,Campbell S. Witt,Simon Mallal +6 more
TL;DR: A fundamental role is supported for HLA-restricted immune responses in driving and shaping HIV-1 evolution in vivo and at a population level the degree of HLA–associated selection in viral sequence was predictive of viral load.
Journal ArticleDOI
Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection.
TL;DR: NRTIs do have an independent contribution to fat wasting, but PI are the predominant influence and may act synergistically with NRTIs, suggesting a non-linear decline in fat over time.
Journal ArticleDOI
Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant
Annalise M Martin,David Nolan,Silvana Gaudieri,Silvana Gaudieri,Coral Ann Almeida,Richard C. Nolan,Ian James,Filipa Carvalho,Elizabeth J. Phillips,Frank T. Christiansen,Frank T. Christiansen,Anthony W. Purcell,James McCluskey,Simon Mallal,Simon Mallal +14 more
TL;DR: The results of fine recombinant genetic mapping in an expanded patient population of 248 consecutive, fully ascertained, abacavir-exposed individuals in the Western Australian HIV Cohort Study indicate that the concurrence of HLA-B*5701 and Hsp70-Hom M493T alleles is necessary for the development of abacvir hypersensitivity.