S
Siyang Zheng
Researcher at Pennsylvania State University
Publications - 138
Citations - 5670
Siyang Zheng is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Circulating tumor cell & Cancer. The author has an hindex of 35, co-authored 127 publications receiving 4745 citations. Previous affiliations of Siyang Zheng include Penn State Cancer Institute & California Institute of Technology.
Papers
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Journal ArticleDOI
Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells
Siyang Zheng,Henry Lin,Jing Quan Liu,Jing Quan Liu,Marija Balic,Ram H. Datar,Richard J. Cote,Yu-Chong Tai +7 more
TL;DR: Development of a parylene membrane microfilter device for single stage capture and electrolysis of circulating tumor cells (CTCs) in human blood, and the potential of this device to allow genomic analysis is presented.
Journal ArticleDOI
Portable Filter-Based Microdevice for Detection and Characterization of Circulating Tumor Cells
Henry K. Lin,Siyang Zheng,Anthony Williams,Marija Balic,Susan Groshen,Howard I. Scher,Martin Fleisher,Walter M. Stadler,Ram H. Datar,Yu-Chong Tai,Richard J. Cote +10 more
TL;DR: A novel parylene membrane filter-based portable microdevice for size-based isolation with high recovery rate and direct on-chip characterization of captured CTC from human peripheral blood has the potential to enable routine CTC analysis in the clinical setting for the effective management of cancer patients.
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3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood
TL;DR: The paper presents and validates this new 3D microfiltration concept for circulation tumor cell enrichment application and provides a highly valuable tool for assessing and characterizing viable enriched circulating tumor cells in both research and clinical settings.
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Self-Assembly of Extracellular Vesicle-like Metal–Organic Framework Nanoparticles for Protection and Intracellular Delivery of Biofunctional Proteins
Gong Cheng,Wen Qing Li,Laura Ha,Xiaohui Han,Sijie Hao,Yuan Wan,Zhigang Wang,Fengping Dong,Xin Zou,Yingwei Mao,Siyang Zheng +10 more
TL;DR: In vitro and in vivo study manifests that the EV-like nanoparticles can not only protect proteins against protease digestion and evade the immune system clearance but also selectively target homotypic tumor sites and promote tumor cell uptake and autonomous release of the guest protein after internalization.
Journal ArticleDOI
A combinatory strategy for detection of live CTCs using microfiltration and a new telomerase-selective adenovirus
Yanchun Ma,Sijie Hao,Shuwen Wang,Shuwen Wang,Yuanjun Zhao,Bora Lim,Ming Lei,David J. Spector,Wafik S. El-Deiry,Siyang Zheng,Jiyue Zhu,Jiyue Zhu +11 more
TL;DR: In this article, a new class of recombinant adenovirus containing regulatory elements that repress the telomerase gene (hTERT) gene in normal cells was reported, which showed better selectivity for replication in cancer cells than in normal ones.