S
Stefan Rose-John
Researcher at University of Kiel
Publications - 659
Citations - 56385
Stefan Rose-John is an academic researcher from University of Kiel. The author has contributed to research in topics: Glycoprotein 130 & Receptor. The author has an hindex of 114, co-authored 633 publications receiving 49525 citations. Previous affiliations of Stefan Rose-John include University of Manchester & German Cancer Research Center.
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Journal ArticleDOI
The pro- and anti-inflammatory properties of the cytokine interleukin-6
TL;DR: It turns out that regenerative or anti-inflammatory activities of interleukin-6 are mediated by classic signaling whereas pro-inflammatory responses of interLEukin -6 are rather mediated by trans-signaling.
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IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
Sergei I. Grivennikov,Eliad Karin,Janoš Terzić,Janoš Terzić,Daniel Mucida,Guann-Yi Yu,Sivakumar Vallabhapurapu,Jürgen Scheller,Stefan Rose-John,Hilde Cheroutre,Lars Eckmann,Michael Karin +11 more
TL;DR: It is demonstrated that IL-6 is a critical tumor promoter during early CAC tumorigenesis and the NF-kappaB-IL-6-Stat3 cascade is an important regulator of the proliferation and survival of tumor-initiating IECs.
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Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.
Raja Atreya,Jonas Mudter,Susetta Finotto,Jürgen Müllberg,Thomas Jostock,Stefan Wirtz,M Schütz,Brigitte Bartsch,Martin H. Holtmann,Christoph Becker,Dennis Strand,J Czaja,Joerg F. Schlaak,Hans-Anton Lehr,Frank Autschbach,G. Schürmann,N Nishimoto,Kazuyuki Yoshizaki,Hiroshi Ito,Tadamitsu Kishimoto,Peter R. Galle,Stefan Rose-John,Markus F. Neurath +22 more
TL;DR: Assessment of the contribution of the pro-inflammatory cytokine interleukin (IL)-6 to the increased resistance of mucosal T cells against apoptosis in Crohn disease indicates that a pathway of T-cell activation driven by IL-6–sIL-6R contributes to the perpetuation of chronic intestinal inflammation.
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IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation
Suzanne M. Hurst,Thomas S. Wilkinson,Rachel M. McLoughlin,Suzanne Jones,Sankichi Horiuchi,Naoki Yamamoto,Stefan Rose-John,Gerald M. Fuller,Nicholas Topley,Simon Arnett Jones +9 more
TL;DR: A role for IL-6 and its soluble receptor (sIL-6R) in controlling this pattern of leukocyte recruitment during peritoneal inflammation is presented and supports transition between the early predominantly neutrophilic stage of an infection and the more sustained mononuclear cell influx.
Journal ArticleDOI
Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T cell Therapy for Acute Lymphoblastic Leukemia
David T. Teachey,David T. Teachey,Simon F. Lacey,Pamela A. Shaw,J. Joseph Melenhorst,Shannon L. Maude,Noelle V. Frey,Edward Pequignot,Vanessa E. Gonzalez,Fang Chen,Jeffrey Finklestein,David M. Barrett,Scott L. Weiss,Julie C. Fitzgerald,Robert A. Berg,Richard Aplenc,Colleen Callahan,Susan R. Rheingold,Zhaohui Zheng,Stefan Rose-John,Jason C. White,Farzana Nazimuddin,Gerald Wertheim,Bruce L. Levine,Carl H. June,David L. Porter,Stephan A. Grupp +26 more
TL;DR: The first models that can accurately predict which patients are likely to develop severe CRS before they become critically ill are developed, which improves understanding of CRS biology and may guide future cytokine-directed therapy.