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Stéphane de Botton
Researcher at Institut Gustave Roussy
Publications - 242
Citations - 11807
Stéphane de Botton is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Myeloid leukemia & Medicine. The author has an hindex of 47, co-authored 209 publications receiving 9568 citations. Previous affiliations of Stéphane de Botton include University of Paris-Sud & University of Limoges.
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Journal ArticleDOI
Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia
Eytan M. Stein,Eytan M. Stein,Courtney D. DiNardo,Daniel A. Pollyea,Amir T. Fathi,Gail J. Roboz,Gail J. Roboz,Jessica K. Altman,Richard Stone,Daniel J. DeAngelo,Ross L. Levine,Ian W. Flinn,Hagop M. Kantarjian,Robert H. Collins,Manish R. Patel,Arthur E. Frankel,Anthony S. Stein,Mikkael A. Sekeres,Ronan T. Swords,Bruno C. Medeiros,Christophe Willekens,Christophe Willekens,Paresh Vyas,Alessandra Tosolini,Qiang Xu,Robert Knight,Katharine E. Yen,Sam Agresta,Stéphane de Botton,Stéphane de Botton,Martin S. Tallman,Martin S. Tallman +31 more
TL;DR: Inducing differentiation of myeloblasts, not cytotoxicity, seems to drive the clinical efficacy of enasidenib, a first-in-class, oral, selective inhibitor of mutant-IDH2 enzymes.
Journal ArticleDOI
Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation
Fang Wang,Jeremy Travins,Byron DeLaBarre,Virginie Penard-Lacronique,Virginie Penard-Lacronique,Virginie Penard-Lacronique,Stefanie Schalm,Erica Hansen,Kimberly Straley,Andrew Kernytsky,Wei Liu,Camelia Gliser,Hua Yang,Stefan Gross,Erin Artin,Véronique Saada,Elena Mylonas,Elena Mylonas,Elena Mylonas,Cyril Quivoron,Cyril Quivoron,Cyril Quivoron,Janeta Popovici-Muller,Jeffrey O. Saunders,Francesco G. Salituro,Shunqi Yan,Stuart Murray,Wentao Wei,Yi Gao,Lenny Dang,Marion Dorsch,Sam Agresta,David P. Schenkein,Scott A. Biller,Shinsan M. Su,Stéphane de Botton,Stéphane de Botton,Stéphane de Botton,Katharine E. Yen +38 more
TL;DR: Evidence is provided that inhibitors targeting mutant IDH2/R140Q could have potential applications as a differentiation therapy for cancer, and a small molecule, AGI-6780, that potently and selectively inhibits the tumor-associated mutant IDh2/ R140Q is developed.
Journal ArticleDOI
Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA).
Claude Preudhomme,Christophe Sagot,Nicolas Boissel,Jean-Michel Cayuela,Isabelle Tigaud,Stéphane de Botton,Xavier Thomas,Emmanuel Raffoux,Charlotte Lamandin,Sylvie Castaigne,Pierre Fenaux,Hervé Dombret +11 more
TL;DR: A risk classification is proposed that includes in the favorable subgroup all patients from the intermediate subgroup displaying CEBPA mutations when not associated with FLT3-ITD, and appears to act as a major bad prognosis factor in patients withCEBPA-mutated AML.
Journal ArticleDOI
Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine
Raphael Itzykson,Sylvain Thepot,Bruno Quesnel,François Dreyfus,Odile Beyne-Rauzy,Pascal Turlure,Norbert Vey,Christian Recher,Caroline Dartigeas,Laurence Legros,Jacques Delaunay,Celia Salanoubat,Sorin Visanica,Aspasia Stamatoullas,Françoise Isnard,Anne Marfaing-Koka,Stéphane de Botton,Youcef Chelghoum,Anne-Laure Taksin,Isabelle Plantier,Shanti Ame,Simone Boehrer,Claude Gardin,C.L. Beach,Lionel Adès,Pierre Fenaux +25 more
TL;DR: Routine tests can identify subgroups of patients with distinct prognosis with AZA treatment, and achievement of hematological improvement in patients who did not obtain complete or partial remission was associated with improved OS.
Journal ArticleDOI
Platelet formation is the consequence of caspase activation within megakaryocytes
Stéphane de Botton,Siham Sabri,Eric Daugas,Yael Zermati,Jacques Emmanuel Guidotti,Olivier Hermine,Guido Kroemer,William Vainchenker,Najet Debili +8 more
TL;DR: It is concluded that proplatelet formation is regulated by a caspase activation limited to only some cellular compartments.