T
Takefumi Doi
Researcher at Osaka University
Publications - 132
Citations - 5708
Takefumi Doi is an academic researcher from Osaka University. The author has contributed to research in topics: Gene expression & Receptor. The author has an hindex of 34, co-authored 122 publications receiving 5304 citations. Previous affiliations of Takefumi Doi include Massachusetts Institute of Technology & Nagoya University.
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Journal ArticleDOI
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Hiroshi Suzuki,Hiroshi Suzuki,Yukiko Kurihara,Motohiro Takeya,Nobuo Kamada,Motoyukl Kataoka,Kou-ichi Jishage,Otoya Ueda,Hisashl Sakaguchi,Takayuki Higashi,Tsukasa Suzuki,Yoshiaki Takashima,Yoshiki Kawabe,Yoshiki Kawabe,Osamu Cynshi,Youichiro Wada,Makoto Honda,Hiroki Kurihara,Hiroyuki Aburatani,Takefumi Doi,Akiyo Matsumoto,Sadahiro Azuma,Tetsuo Noda,Yutaka Toyoda,Hiroshige Itakura,Yoshio Yazaki,Seikoh Horiuchi,Kiyoshi Takahashi,J. Kar Kruijt,Theo J.C. Van Berkel,Urs P. Steinbrecher,Shun Ishibashi,Nobuyo Maeda,Siamon Gordon,Tatsuhiko Kodama +34 more
TL;DR: It is shown that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in an animal deficient in apolipoprotein E, indicating that MSr-A may play a part in host defence against pathogens.
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Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome
Toshiya Tanaka,Joji Yamamoto,Satoshi Iwasaki,Hiroshi Asaba,Hiroki Hamura,Yukio Ikeda,Mitsuhiro Watanabe,Kenta Magoori,Ryoichi X. Ioka,Keisuke Tachibana,Yuichiro Watanabe,Yasutoshi Uchiyama,Koichi Sumi,Haruhisa Iguchi,Sadayoshi Ito,Takefumi Doi,Takao Hamakubo,Makoto Naito,Johan Auwerx,Masashi Yanagisawa,Tatsuhiko Kodama,Juro Sakai +21 more
TL;DR: Analysis of rat L6 myotubes treated with the PPARδ subtype-selective agonist, GW501516, by the Affymetrix oligonucleotide microarrays revealed that PPAR Δ is pivotal to control the program for fatty acid oxidation in the skeletal muscle, thereby ameliorating obesity and insulin resistance through its activation in obese animals.
Journal ArticleDOI
Charged collagen structure mediates the recognition of negatively charged macromolecules by macrophage scavenger receptors
Takefumi Doi,K Higashino,Yukiko Kurihara,Yoh Wada,Toru Miyazaki,Hironobu Nakamura,Seiichi Uesugi,Takeshi Imanishi,Yoshiki Kawabe,H Itakura +9 more
TL;DR: It is proposed that a "charged collagen" structure containing a lysine cluster forms a positively charged groove which specifically interacts with negatively charged ligands.
Journal ArticleDOI
The Role of PPARs in Cancer.
TL;DR: The function of PPARs in tumor growth is reviewed and it is shown that these receptors are molecular targets for the development of drugs treating metabolic syndrome and cancer cell growth.
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H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation
Yoshihiro Matsumura,Ryo Nakaki,Takeshi Inagaki,Ayano Yoshida,Yuka Kano,Hiroshi Kimura,Toshiya Tanaka,Shuichi Tsutsumi,Mitsuyoshi Nakao,Takefumi Doi,Kiyoko Fukami,Timothy F. Osborne,Tatsuhiko Kodama,Hiroyuki Aburatani,Juro Sakai +14 more
TL;DR: This paper showed lineage-specific gene-body DNA methylation recruits H3K9 methyltransferase SETDB1, which methylates H 3K9 immediately downstream of transcription start sites marked with h3K4me3 to establish the bivalent domain.