scispace - formally typeset
T

Timothy F. Osborne

Researcher at Johns Hopkins University School of Medicine

Publications -  129
Citations -  15980

Timothy F. Osborne is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Sterol regulatory element-binding protein & Transcription factor. The author has an hindex of 55, co-authored 120 publications receiving 14002 citations. Previous affiliations of Timothy F. Osborne include Discovery Institute & University of California, Irvine.

Papers
More filters
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

William A. Freed-Pastor, +19 more
- 20 Jan 2012 - 
TL;DR: It is found that mutant p53 depletion is sufficient to phenotypically revert breast cancer cells to a more acinar-like morphology, which implicate the mevalonate pathway as a therapeutic target for tumors bearing mutations in p53.
Journal ArticleDOI

Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors.

Sean B. Joseph, +8 more
- 29 Mar 2002 - 
TL;DR: It is demonstrated that in addition to tandem SREBP sites, the FASpromoter contains a high affinity binding site for the LXR/RXR heterodimer that is conserved in diverse animal species including birds, rodents, and humans.
Journal ArticleDOI

Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action

Timothy F. Osborne
- 20 Oct 2000 - 
TL;DR: The sterol regulatory element-binding proteins (SREBPs) were first identified by two groups working independently on cholesterol metabolism and fat cell differentiation and have a unique dual DNA binding specificity, which is discussed below.
Journal ArticleDOI

SREBPs: Metabolic Integrators in Physiology and Metabolism

Tae Il Jeon, +1 more
- 01 Feb 2012 - 
TL;DR: Genetic and genome-wide approaches highlight new functions for SREBPs in connecting lipid metabolism with other cellular processes where lipid pathway flux affects physiologic or pathophysiologic adaptation, such as cancer, steatosis, and innate immunity.