T
Tatiana Takiishi
Researcher at Katholieke Universiteit Leuven
Publications - 20
Citations - 2526
Tatiana Takiishi is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 12, co-authored 17 publications receiving 1989 citations. Previous affiliations of Tatiana Takiishi include University of São Paulo & Catholic University of Leuven.
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Vitamin D: modulator of the immune system.
TL;DR: 1,25(OH)(2)D(3) is described as an immunomodulator targeting various immune cells, including monocytes, macrophages, dendritic cells (DCs), as well as T-lymphocytes and B-LYmphocytes, hence modulating both innate and adaptive immune responses.
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Intestinal barrier and gut microbiota: Shaping our immune responses throughout life.
TL;DR: This review will be focused on the development of the intestinal barrier and its function in host immune defense and how gut microbiome composition throughout life can affect this role.
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Vitamin D and Diabetes
TL;DR: In this article, a link between vitamin D deficiency in early life and the later onset of type 1 diabetes was found, and pharmacological doses of 1α,25dihydroxyvitamin D3, or its structural analogues, have been shown to delay the onset of diabetes, mainly through immune modulation.
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Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice
Tatiana Takiishi,Hannelie Korf,Tom Van Belle,Sofie Robert,Fabio Arturo Grieco,Silvia Caluwaerts,Letizia Galleri,Isabella Spagnuolo,Lothar Steidler,Karolien Van Huynegem,Pieter Demetter,Clive Wasserfall,Mark A. Atkinson,Francesco Dotta,Pieter Rottiers,Conny Gysemans,Chantal Mathieu +16 more
TL;DR: It is shown that combination therapy with low-dose systemic anti-CD3 stably reverted diabetes in NOD mice and increased frequencies of local Tregs, which not only accumulated in the pancreatic islets, but also suppressed immune response in an autoantigen-specific way, allowing reversal of established autoimmune diabetes.
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1,25-Dihydroxyvitamin D3 curtails the inflammatory and T cell stimulatory capacity of macrophages through an IL-10-dependent mechanism
Hannelie Korf,Mathias Wenes,Benoit Stijlemans,Benoit Stijlemans,Tatiana Takiishi,Sofie Robert,Michela Miani,Decio L. Eizirik,Conny Gysemans,Chantal Mathieu +9 more
TL;DR: The ability of the natural VDR ligand, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) to interfere in inflammatory and T cell stimulatory capacity of macrophages, in particular within a chronic inflammatory disease features of experimental type 1 diabetes (T1D).