T
Todd A. Fehniger
Researcher at Washington University in St. Louis
Publications - 202
Citations - 18903
Todd A. Fehniger is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Interleukin 12 & Interleukin 21. The author has an hindex of 52, co-authored 171 publications receiving 16307 citations. Previous affiliations of Todd A. Fehniger include Ohio State University & University of Washington.
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Journal ArticleDOI
The biology of human natural killer-cell subsets.
TL;DR: Human natural killer cells comprise approximately 15% of all circulating lymphocytes and have the capacity to produce abundant cytokines following activation of monocytes, but has low natural cytotoxicity and is CD16(dim) or CD16(-).
Journal ArticleDOI
Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset
Megan A. Cooper,Todd A. Fehniger,Sarah C. Turner,Kenneth S. Chen,Bobak A. Ghaheri,Tariq Ghayur,William E. Carson,Michael A. Caligiuri +7 more
TL;DR: It is proposed that human CD56bright NK cells have a unique functional role in the innate immune response as the primary source of NK cell–derived immunoregulatory cytokines, regulated in part by differential monokine production.
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Interleukin 15: biology and relevance to human disease
TL;DR: The cloning of interleukin (IL)-15 and IL-2 have similar biologic properties in vitro, consistent with their shared receptor (R) signaling components (IL-2/15Rβγc).
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CD56bright natural killer cells are present in human lymph nodes and are activated by T cell–derived IL-2: a potential new link between adaptive and innate immunity
Todd A. Fehniger,Megan A. Cooper,Gerard J. Nuovo,Marina Cella,Fabio Facchetti,Marco Colonna,Michael A. Caligiuri +6 more
TL;DR: It is demonstrated that CD56(bright) NK cells are present in human lymph nodes and that endogenous T cell-derived IL-2, acting through the NK high-affinityIL-2 receptor, costimulates CD56 (bright)NK cells to secrete IFN-gamma.
Journal ArticleDOI
Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance
Xuefang Cao,Sheng F. Cai,Todd A. Fehniger,Jiling Song,Lynne Collins,David Piwnica-Worms,Timothy J. Ley +6 more
TL;DR: It is shown here that granzyme B-deficient mice clear both allogeneic and syngeneic tumor cell lines more efficiently than do wild-type (WT) mice and Granzyme B and perforin are relevant for Treg cell-mediated suppression of tumor clearance in vivo.