T
Travis C. Jackson
Researcher at University of Pittsburgh
Publications - 59
Citations - 1399
Travis C. Jackson is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Neuroprotection & Traumatic brain injury. The author has an hindex of 20, co-authored 53 publications receiving 1131 citations. Previous affiliations of Travis C. Jackson include McKnight Brain Institute & Boston Children's Hospital.
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Journal ArticleDOI
A mitochondrial pathway for biosynthesis of lipid mediators.
Yulia Y. Tyurina,Samuel M. Poloyac,Vladimir A. Tyurin,Alexander A. Kapralov,Jianfei Jiang,Tamil S. Anthonymuthu,Valentina I. Kapralova,Anna S. Vikulina,Mi-Yeon Jung,Michael W. Epperly,Dariush Mohammadyani,Judith Klein-Seetharaman,Travis C. Jackson,Patrick M. Kochanek,Bruce R. Pitt,Joel S. Greenberger,Yury A. Vladimirov,Hülya Bayır,Valerian E. Kagan +18 more
TL;DR: This work reports that a range of diversified polyunsaturated molecular species derived from a mitochondria-specific phospholipid, cardiolipin, are oxidized by the intermembrane space hemoprotein, cytochrome c, thus generating multiple oxygenated fatty acids, including well known lipid mediators.
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Emerging therapies in traumatic brain injury.
Patrick M. Kochanek,Travis C. Jackson,Nikki Miller Ferguson,Shaun W. Carlson,Dennis W. Simon,Erik Brockman,Jing Ji,Hülya Bayır,Samuel M. Poloyac,Amy K. Wagner,Anthony E. Kline,Philip E. Empey,Robert S. B. Clark,Edwin K. Jackson,C. Edward Dixon +14 more
TL;DR: The authors address putative new therapies for TBI across both the spectrum of injury severity and the continuum of care, from the field to rehabilitation, using a mechanism-based approach.
Journal ArticleDOI
Estrogen effects on cognition and hippocampal transcription in middle-aged mice.
TL;DR: The results indicate that estrogen treatment in middle-aged animals may promote hippocampal health during the aging process and alter the expression of genes related to transcriptional regulation, biosynthesis, growth, neuroprotection, and elements of cell signaling pathways.
Journal ArticleDOI
Contribution of estrogen receptor subtypes, ERα, ERβ, and GPER1 in rapid estradiol-mediated enhancement of hippocampal synaptic transmission in mice.
TL;DR: The results suggest that ERK activation and enhancement of synaptic transmission by EB involves multiple estrogen receptor subtypes, and that the increase in synaptic transmission is blocked by inhibition of extracellular signal‐regulated kinase (ERK) activity.
Journal ArticleDOI
Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy
Patrick M. Kochanek,Helen M. Bramlett,Helen M. Bramlett,Deborah A. Shear,C. Edward Dixon,Stefania Mondello,W. Dalton Dietrich,Ronald L. Hayes,Kevin K.W. Wang,Samuel M. Poloyac,Philip E. Empey,John T. Povlishock,Andrea Mountney,Megan Browning,Ying Deng-Bryant,Hong Q. Yan,Travis C. Jackson,Michael Catania,Olena Glushakova,Steven P. Richieri,Frank C. Tortella +20 more
TL;DR: Based on the results generated from the first five therapies tested within the exacting approach used by OBTT, four (nicotinamide, erythropoietin, cyclosporine A, and simvastatin) performed below or well below what was expected based on the published literature.