V
Vincent Plagnol
Researcher at University College London
Publications - 223
Citations - 28503
Vincent Plagnol is an academic researcher from University College London. The author has contributed to research in topics: Genome-wide association study & Exome sequencing. The author has an hindex of 71, co-authored 221 publications receiving 24649 citations. Previous affiliations of Vincent Plagnol include University of Southern California & University of Bristol.
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Journal ArticleDOI
Bayesian test for colocalisation between pairs of genetic association studies using summary statistics.
Claudia Giambartolomei,Damjan Vukcevic,Eric E. Schadt,Lude Franke,Aroon D. Hingorani,Chris Wallace,Vincent Plagnol +6 more
TL;DR: A novel statistical methodology to assess whether two association signals are consistent with a shared causal variant and the ability to derive the output statistics from single SNP summary statistics, making it possible to perform systematic meta-analysis type comparisons across multiple GWAS datasets is developed.
Journal ArticleDOI
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Jeffrey C. Barrett,David Clayton,Patrick Concannon,Beena Akolkar,Jason D. Cooper,Henry A. Erlich,Cécile Julier,Grant Morahan,Jørn Nerup,Concepcion Nierras,Vincent Plagnol,Flemming Pociot,Helen Schuilenburg,Deborah J. Smyth,Helen Stevens,John A. Todd,Neil Walker,Stephen S. Rich +17 more
TL;DR: The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.
Journal ArticleDOI
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
John A. Todd,Neil Walker,Jason D. Cooper,Deborah J. Smyth,Kate Downes,Vincent Plagnol,Rebecca Bailey,Sergey Nejentsev,Sarah F. Field,Felicity Payne,Christopher E. Lowe,Jeffrey S. Szeszko,Jason P. Hafler,Lauren R. Zeitels,Jennie H M Yang,Adrian Vella,Adrian Vella,Sarah Nutland,Helen Stevens,Helen Schuilenburg,Gillian Coleman,Meeta Maisuria,William Meadows,Luc J. Smink,Barry C. Healy,Oliver S. Burren,Alex C. Lam,Nigel R. Ovington,James E. Allen,Ellen C. Adlem,H. T. Leung,Chris Wallace,Joanna M. M. Howson,Cristian Guja,Constantin Ionescu-Tirgoviste,Matthew J. Simmonds,Joanne M. Heward,Stephen C. L. Gough,David B. Dunger,Linda S. Wicker,David Clayton +40 more
TL;DR: This study increases the number of T1D loci with compelling evidence from six to at least ten, with evidence for chromosome 18q22 and 18p11, which showed association with autoimmune thyroid disease.
Journal ArticleDOI
Markov chain Monte Carlo without likelihoods
TL;DR: A Markov chain Monte Carlo method for generating observations from a posterior distribution without the use of likelihoods is presented, which can be used in frequentist applications, in particular for maximum-likelihood estimation.
Journal ArticleDOI
The pattern of polymorphism in Arabidopsis thaliana.
Magnus Nordborg,Tina T. Hu,Yoko Ishino,Jinal Jhaveri,Christopher Toomajian,Honggang Zheng,E. G. Bakker,Peter Calabrese,Jean Gladstone,Rana Goyal,Mattias Jakobsson,Sung K. Kim,Yuri Morozov,Badri Padhukasahasram,Vincent Plagnol,Noah A. Rosenberg,Chitiksha Shah,Jeffrey D. Wall,Jue Wang,Keyan Zhao,Theodore S. Kalbfleisch,Vincent P. Schulz,Martin Kreitman,Joy Bergelson +23 more
TL;DR: The data support the utility of A. thaliana as a model for evolutionary functional genomics and suggest there is a genome-wide excess of rare alleles and too much variation between genomic regions in the level of polymorphism.