Y
Yu-Jen Chen
Researcher at Mackay Memorial Hospital
Publications - 162
Citations - 3038
Yu-Jen Chen is an academic researcher from Mackay Memorial Hospital. The author has contributed to research in topics: Radiation therapy & Medicine. The author has an hindex of 27, co-authored 140 publications receiving 2284 citations. Previous affiliations of Yu-Jen Chen include China Medical University (Taiwan) & National Yang-Ming University.
Papers
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Journal ArticleDOI
Computer-aided classification of lung nodules on computed tomography images via deep learning technique.
TL;DR: This study attempted to simplify the image analysis pipeline of conventional CAD with deep learning techniques and introduced models of a deep belief network and a convolutional neural network in the context of nodule classification in computed tomography images.
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Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer.
Ching-Wei Chang,Ching-Wei Chang,Ching-Wei Chang,Hung Chang Lee,Hung Chang Lee,Hung Chang Lee,Li Hui Li,Jen Shiu Chiang Chiau,Tsang En Wang,Tsang En Wang,Wei Hung Chuang,Ming Jen Chen,Ming Jen Chen,Horng Yuan Wang,Horng Yuan Wang,Shou Chuan Shih,Shou Chuan Shih,Chia Yuan Liu,Chia Yuan Liu,Chia Yuan Liu,Tung Hu Tsai,Tung Hu Tsai,Yu-Jen Chen,Yu-Jen Chen,Yu-Jen Chen +24 more
TL;DR: Importantly, FMT did not cause bacteremia and safely alleviated FOLFOX-induced intestinal mucositis in colorectal cancer-bearing mice, suggesting the putative mechanism may involve the gut microbiota TLR-MyD88-NF-κB signaling pathway in mice with implanted coloreCTal carcinoma cells.
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Lactobacillus casei Variety rhamnosus Probiotic Preventively Attenuates 5-Fluorouracil/Oxaliplatin-Induced Intestinal Injury in a Syngeneic Colorectal Cancer Model.
Ching-Wei Chang,Chia Yuan Liu,Hung Chang Lee,Yen Hua Huang,Li Hui Li,Jen Shiu Chiang Chiau,Tsang En Wang,Cheng Hsin Chu,Cheng Hsin Chu,Shou Chuan Shih,Shou Chuan Shih,Tung Hu Tsai,Tung Hu Tsai,Yu-Jen Chen +13 more
TL;DR: The oral probiotic Lcr35 prevented FOLFOX-induced intestinal mucositis in colorectal cancer-bearing mice, and the putative mechanism might involve modulation of gut microbiota and proinflammatory responses with suppression of intrinsic apoptosis in intestinal injury.
Journal ArticleDOI
Caffeic acid phenethyl ester induces apoptosis of human pancreatic cancer cells involving caspase and mitochondrial dysfunction.
Ming-Jen Chen,Wen-Hsiung Chang,Ching-Chung Lin,Chia-Yuan Liu,Tsang-En Wang,Cheng-Hsin Chu,Shou-Chuan Shih,Yu-Jen Chen +7 more
TL;DR: The results suggest that CAPE is a potent apoptosis-inducing agent whose action is accompanied by mitochondrial dysfunction and activation of caspase-3/casp enzyme-related mechanism in CAPE-induced apoptosis.
Journal ArticleDOI
Pretreatment with a Heat-Killed Probiotic Modulates the NLRP3 Inflammasome and Attenuates Colitis-Associated Colorectal Cancer in Mice
I-Che Chung,Chun-Nan OuYang,Sheng-Ning Yuan,Hsin-Chung Lin,Kuo-Yang Huang,Pao-Shu Wu,Chia-Yuan Liu,Kuen-Jou Tsai,Lai-Keng Loi,Yu-Jen Chen,An-Ko Chung,David M. Ojcius,Yu-Sun Chang,Yu-Sun Chang,Lih-Chyang Chen +14 more
TL;DR: Application of the inactivated probiotic, E. faecalis, may be a useful and safe strategy for attenuation of NLRP3-mediated colitis and inflammation-associated colon carcinogenesis.