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Yuhong Fan
Researcher at Georgia Institute of Technology
Publications - 36
Citations - 4679
Yuhong Fan is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 24, co-authored 35 publications receiving 4232 citations. Previous affiliations of Yuhong Fan include Albert Einstein College of Medicine & Yeshiva University.
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Journal ArticleDOI
Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
Jessica Okosun,Csaba Bödör,Jun Wang,Shamzah Araf,Cheng Yuan Yang,Chenyi Pan,Sören Boller,Davide Cittaro,Monika Bozek,Sameena Iqbal,Janet Matthews,David Wrench,Jacek Marzec,Kiran Tawana,Nikolay Popov,Ciaran O'Riain,Derville O’Shea,Emanuela Carlotti,Andrew Davies,Charles H. Lawrie,András Matolcsy,Maria Calaminici,Andrew Norton,Richard J. Byers,Charles A. Mein,Elia Stupka,T. Andrew Lister,Georg Lenz,Silvia Montoto,John G. Gribben,Yuhong Fan,Rudolf Grosschedl,Claude Chelala,Jude Fitzgibbon +33 more
TL;DR: This study provides new insights into the genetic basis of follicular lymphoma and the clonal dynamics of transformation and suggests that personalizing therapies to target key genetic alterations in the CPC represents an attractive therapeutic strategy.
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Histone H1 Depletion in Mammals Alters Global Chromatin Structure but Causes Specific Changes in Gene Regulation
Yuhong Fan,Tatiana Nikitina,Jie Zhao,Tomara J. Fleury,Riddhi Bhattacharyya,Eric E. Bouhassira,Arnold Stein,Christopher L. Woodcock,Arthur I. Skoultchi +8 more
TL;DR: Results indicate that linker histones can participate in epigenetic regulation of gene expression by contributing to the maintenance or establishment of specific DNA methylation patterns.
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Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination
Ragnhild Eskeland,Martin Leeb,Graeme R. Grimes,Clémence Kress,Shelagh Boyle,Duncan Sproul,Nick Gilbert,Yuhong Fan,Arthur I. Skoultchi,Anton Wutz,Wendy A. Bickmore +10 more
TL;DR: It is suggested that Ring1B-mediated chromatin compaction acts to directly limit transcription in vivo and to restore a compact chromatin state and to repress Hox gene expression is not dependent on its histone ubiquitination activity.
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Role of linker histone in chromatin structure and function: H1 stoichiometry and nucleosome repeat length
TL;DR: It is clear that the 1 H1 per nucleosome paradigm for higher eukaryotes is the exception rather than the rule, and this prompts a reappraisal of the role of linker histone as an obligatory chromatin architectural protein.
Journal ArticleDOI
H1 linker histones are essential for mouse development and affect nucleosome spacing in vivo.
Yuhong Fan,Tatiana Nikitina,Elizabeth M. Morin-Kensicki,Jie Zhao,Terry Magnuson,Christopher L. Woodcock,Arthur I. Skoultchi +6 more
TL;DR: It is demonstrated that the total amount of H1 is crucial for proper embryonic development and inactivating the genes for three mouse H1 subtypes showed that linker histones are essential for mammalian development.